Respiratory cancer in chrysotile textile and mining industries: exposure inferences from lung analysis.
Respiratory cancer in chrysotile textile and mining industries: exposure inferences from lung analysis.
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温石棉纺织和采矿业中的呼吸道癌：肺部分析的暴露推断。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
R. Harley
中科院分区：
文献类型：
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作者：
P. Sébastien;J. Mcdonald;A. McDonald;B. Case;R. Harley
在南卡罗来纳查尔斯顿的石棉纺织工人中，在相同的累积暴露量下，患呼吸道癌的风险要比暴露于同一来源的魁北克矿工和磨坊主高得多，为了解释这一点，研究人员用透射电子显微镜分析了尸检时采集的161个死者肺组织样本。总共鉴定出1828根温石棉纤维和3270根透闪石纤维；在两个队列中，透闪石占主导地位，纤维尺寸非常相似。对(a) 32名配对受试者的肺纤维浓度进行统计分析，这些配对受试者的工作时间和从上次工作到死亡的时间相匹配，(b)按相同时间变量分层的136名受试者。两项分析都表明，魁北克/查尔斯顿肺组织中温石棉纤维浓度比甚至高于相应的估计暴露强度比（mpcf）。考虑到回归分析表明，魁北克塞特福德矿粉尘中透闪石的比例可能比查尔斯顿高2.5倍，肺中透闪石纤维浓度的配对和分层分析结果与温石棉几乎相同。结论是，无论是纤维尺寸差异还是暴露估计误差都不能解释石棉纺织工人中观察到的肺癌风险较高。过去石棉纺织厂用于控制粉尘的矿物油可能具有共同致癌作用，这提供了值得考虑的另一种假设。
In an attempt to explain the much greater risk of respiratory cancer at the same cumulative exposure in asbestos textile workers in Charleston, South Carolina, than in Quebec miners and millers, both exposed to chrysotile from the same source, 161 lung tissue samples taken at necropsy from dead cohort members were analysed by transmission electron microscopy. Altogether 1828 chrysotile and 3270 tremolite fibres were identified; in both cohorts tremolite predominated and fibre dimensions were closely similar. Lung fibre concentrations were analysed statistically (a) in 32 paired subjects matched for duration of employment and time from last employment to death and (b) in 136 subjects stratified by the same time variables. Both analyses indicated that the Quebec/Charleston ratios for chrysotile fibre concentration in lung tissue were even higher than the corresponding ratios of estimated exposure intensity (mpcf). After allowance for the fact that regression analyses suggested that the proportion of tremolite in dust was probably 2.5 times higher in Thetford Mines, Quebec, than in Charleston, the results from both matched pair and stratification analyses of tremolite fibre concentrations in lung were almost the same as for chrysotile. It is concluded that neither fibre dimensional differences nor errors in estimation of exposure can explain the higher risks of lung cancer observed in asbestos textile workers. The possible co-carcinogenic role of mineral oil used in the past in asbestos textile plants to control dust provides an alternative hypothesis deserving consideration.