Limits to predicting evolution: Insights from a long-term experiment with Escherichia coli
Limits to predicting evolution: Insights from a long-term experiment with Escherichia coli
复制标题
预测进化的局限性：来自大肠杆菌长期实验的见解
DOI：
10.1007/978-3-030-39831-6_7
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Barrick, J.E.
中科院分区：
文献类型：
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作者：
Barrick, J.E.
我们无法预测细胞群将如何进化，这是对人类健康和生物工程的根本挑战。在医学领域，人们希望预测和阻止，或者至少有时间为潜在的灾难性事件做好充分准备，例如新病原体的出现、耐药性的传播以及慢性感染和癌症的进展。在生物工程中，人们希望停止或至少延迟使设计功能失活的进化，以使基因工程和合成生物学更加可靠和高效。在更大的范围内，人们还想预测重组DNA或某种物种的存在何时可能对自然或文明构成威胁（如果它有可能进化成有害的）。
Our inability to predict how populations of cells will evolve is a fundamental challenge to human health and biological engineering. In medicine, one would like to predict and thwart, or at least have time to adequately prepare for potentially catastrophic events such as the emergence of new pathogens, the spread of drug resistance, and the progression of chronic infections and cancers. In bioengineering, one would like to stop, or at least delay, evolution that inactivates a designed function, in order to make genetic engineering and synthetic biology more reliable and efficient. On a larger scale, one would also like to predict when the presence of recombinant DNA or a certain species might pose a threat to nature or civilization if it has the potential to evolve to become harmful.