Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism.
Citrus fruit intake is associated with lower serum bilirubin concentration among women with the UGT1A1*28 polymorphism.
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DOI：
10.3945/jn.108.097279
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发表时间：
2009-03
影响因子：
4.2
通讯作者：
Lampe, Johanna W.
中科院分区：
文献类型：
--
作者：
Saracino, Misty R.;Bigler, Jeannette;Schwarz, Yvonne;Chang, Jyh-Lurn;Li, Shiuying;Li, Lin;White, Emily;Potter, John D.;Lampe, Johanna W.
UDP-葡萄糖醛酸基转移酶 (UGT) 1A1 葡萄糖醛酸化胆红素、雌激素和异生化合物。 UGT1A1*28 多态性由于 7 个胸腺嘧啶-腺嘌呤 (TA) 重复而不是更常见的 6 个 TA 重复而导致启动子活性较低。此前，我们发现，当随机接受高水果和蔬菜 (F&V) 饮食时，UGT1A1*28 纯合子个体 (7/7) 的血清胆红素 (UGT1A1 活性标志物) 较低，而野生型 (6/6) 和杂合子 (6/7) 基因型个体中没有观察到任何影响。我们的目标是确定是否可以在观察性研究中检测基因型-饮食对胆红素浓度的相互作用。从西雅图地区招募的健康不吸烟男性 (n=146) 和女性 (n=147) 提供了血液样本用于基因分型和胆红素测量。我们使用多元线性回归来评估基于 FFQ 的 UGT1A1 基因型、胆红素浓度和特定 F&V [十字花科蔬菜、柑橘类水果和大豆食品 (n=268)] 消耗之间的关系，以及基于 3 d 的来自 6 个植物科 [十字花科、蔷薇科、芸香科、伞形科、茄科和豆科 (n=261)] 的 F&V 之间的关系。食品记录。我们观察到女性中 UGT1A1 基因型与柑橘消费之间存在显着的相互作用。每天摄入 0.5 份或更多柑橘类水果或芸香科植物食物的 7/7 基因型女性，其血清胆红素比摄入较少的相同基因型女性低约 30%，而 6/6 和 6/7 基因型在摄入量方面没有差异（交互作用 P 分别 = 0.006 和 0.03）。这些结果表明，食用柑橘可能会增加 7/7 基因型女性的 UGT1A1 活性。
UDP-glucuronosyltransferase (UGT) 1A1 glucuronidates bilirubin, estrogens, and xenobiotic compounds. The UGT1A1*28 polymorphism results in lower promoter activity due to 7 thymine-adenine (TA) repeats, rather than the more common 6 TA repeats. Previously, we showed that serum bilirubin, a marker of UGT1A1 activity, was lower among individuals homozygous for the UGT1A1*28 polymorphism (7/7) when randomized to a high fruit and vegetable (F&V) diet, whereas no effect was seen in individuals with the wild-type (6/6) and heterozygous (6/7) genotypes. Our objective here was to determine if we could detect genotype-diet interactions on bilirubin concentrations in an observational study. Healthy non-smoking men (n=146) and women (n=147), recruited from the Seattle area, provided blood samples for genotyping and bilirubin measurements. We used multiple linear regression to assess the relationships between UGT1A1 genotype, bilirubin concentrations and consumption of specific F&V [cruciferous vegetables, citrus fruits, and soy foods (n=268)] based on FFQ, and F&V from 6 botanical families [Cruciferae, Rosaceae, Rutaceae, Umbelliferae, Solanaceae and Leguminosae (n=261)] based on 3 d food records. We observed a significant interaction of UGT1A1 genotype and citrus consumption among women. Women with the 7/7 genotype who consumed 0.5 or more daily servings of citrus fruit or foods from the Rutaceae botanical family had ~30% lower serum bilirubin than those with the same genotype who consumed less, while 6/6 and 6/7 genotypes did not differ by consumption (P for interaction = 0.006 and 0.03 respectively). These results suggest that citrus consumption may increase UGT1A1 activity among women with the 7/7 genotype.
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影响因子：
4.7
作者：
Angus, WGR;Larsen, MC;Jefcoate, CR
通讯作者：
Jefcoate, CR
影响因子：
2.9
作者：
Dingley, KH;Ubick, EA;Clifford, AJ
通讯作者：
Clifford, AJ
影响因子：
2.6
作者：
Hsieh, Tsai-Yuan;Shiu, Tzu-Yue;Chao, You-Chen
通讯作者：
Chao, You-Chen
DOI：
10.1097/00008571-199906000-00009
发表时间：
1999-06-01
期刊：
PHARMACOGENETICS
影响因子：
--
作者：
Lampe, JW;Bigler, J;Potter, JD
通讯作者：
Potter, JD
影响因子：
4.1
作者：
Malfatti, MA;Felton, JS
通讯作者：
Felton, JS