Exotines A and B, Two Heterodimers of Isopentenyl-Substituted Indole and Coumarin Derivatives from Murraya exotica
Exotines A and B, Two Heterodimers of Isopentenyl-Substituted Indole and Coumarin Derivatives from Murraya exotica
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Exotines A 和 B，来自九里香的异戊烯基取代的吲哚和香豆素衍生物的两种异二聚体。
DOI：
10.1021/acs.orglett.5b02230
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发表时间：
2015-09-04
期刊：
影响因子：
5.2
通讯作者：
Jiang, Yong
中科院分区：
文献类型：
--
作者：
Liu, Bing-Yu;Zhang, Chen;Jiang, Yong
从九里香（Murraya exotica）的根中分离得到两个异戊烯基取代的吲哚和香豆素衍生物的异二聚体外泌素A和B（1和2）。通过核磁共振和质谱数据分析确定了它们的结构，并通过单晶X-射线晶体学分析和电子捕获密度（ECD）计算确定了它们的绝对构型。化合物1和2显示出抑制脂多糖诱导的BV-2小胶质细胞中一氧化氮的产生，IC 50值分别为9.2和39.9 μM。
Exotines A and B (1 and 2), two heterodimers of isopentenyl-substituted indole and coumarin derivatives linked through a new fused heptacyclic ring system, were isolated from the roots of Murraya exotica. Their structures were established by comprehensive NMR and MS spectroscopic data analysis, and the absolute configurations were determined by single-crystal X-ray crystallographic analysis and ECD calculations. Compounds 1 and 2 showed inhibition of nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells with IC50 values of 9.2 and 39.9 μM, respectively.