The demonstration of serum interleukin 6-8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behcet's disease with ocular involvement
The demonstration of serum interleukin 6-8, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Behcet's disease with ocular involvement
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DOI：
10.1076/ocii.12.1.53.28062
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发表时间：
2004-03-01
影响因子：
3.3
通讯作者：
Aridogan, BC
中科院分区：
文献类型：
--
作者：
Bardak, Y;Aridogan, BC
目的：探讨白塞病（BD）患者眼部免疫功能的变化。方法：24例活动性葡萄膜炎且无其他疾病表现的BD患者被纳入I-a组。在恢复期对相同患者进行重新评估，并将其分配至I-c组。此外，24名年龄和性别匹配的健康对照（第II组）被纳入研究。测量并比较组I-a、I-c和11中免疫球蛋白（IG）A、IgM、补体（C）（3）、C-4、白细胞介素（IL）-6、IL-8和肿瘤坏死因子-α（TNF-α）的血清水平。结果：I-a组伊加、C-3、C-4、IL-6、IL-8和TNF-α水平高于I-c和II组。结论：伊加、C-3、C-4、IL-6、IL-8和TNF-α介导的机制可能是BD眼部病变的重要机制。
Purpose: To investigate whether there are alterations in the humoral immune system in patients with Behcet's disease (BD) with ocular involvement. Methods: Twenty-four BD patients with active uveitis and without any other manifestations of the disease were included in Group I-a. The same patients were reassessed during the convalescence period and assigned to Group I-c. Moreover, 24 age- and sex-matched healthy controls (Group II) were included in the study. Serum levels of immunoglobulin (Ig) A, IgM, complement (C)(3), C-4, interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-alpha) in Groups I-a, I-c, and 11 were measured and compared. Results: IgA, C-3, C-4, IL-6, IL-8, and TNF-alpha levels were higher in Group I-a than in Groups I-c and II. Conclusions: IgA-, C-3-, C-4-, IL6-, IL8-, and TNF-alpha-mediated mechanisms might be responsible for ocular lesions in BD.