A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis
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DOI：
10.1016/j.joca.2005.04.014
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发表时间：
2005-09-01
影响因子：
7
通讯作者：
Jones, G
中科院分区：
文献类型：
--
作者：
Srikanth, VK;Fryer, JL;Jones, G
目的：通过对OA患病率、发病率和severity.Methods的性别差异进行荟萃分析，解决骨关节炎（OA）性别差异的不确定性。随机效应荟萃分析提供了合并的男性与女性患病和偶发OA的风险和率比，以及OA严重程度的标准化平均差异（SMD），荟萃回归用于调查异质性的来源。男性膝关节[风险比（RR）0.63，95% CI 0.53-0.75]和手部[RR 0.81，95% CI 0.73-0.90]，但其他部位不适用。年龄< 55岁的男性患颈椎骨关节炎的风险更大[RR 1.29，95%CI 1.18-1.41]。男性膝关节[发病率比（IRR）0.55，95% CI 0.32-0.94]和髋关节[IRR 0.64，95% CI 0.48-0.86]的OA发生率也显著降低，手部的趋势[IRR 0.65，95%置信区间（CI）0.35-1.20]。女性，尤其是>= 55岁的女性，膝关节OA更严重，而其他部位则不严重。在患病率的性别差异的估计heteroadherence基本上解释了年龄和其他研究设计因素，包括方法OA definition.Conclusions：结果表明，存在的OA患病率和发病率的性别差异，女性一般处于较高的风险。女性也往往有更严重的膝关节OA，特别是在绝经年龄后。这些部位的差异表明需要进一步研究以探索OA的潜在机制。(c)2005年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To resolve uncertainty regarding sex differences in osteoarthritis (OA) by performing a meta-analysis of sex differences in OA prevalence, incidence and severity.Methods: Standard search strategies for population-based studies of OA providing sex-specific data. Random effects meta-analysis to provide pooled male vs female risk and rate ratios for prevalent and incident OA, and standardized mean differences (SMD) for OA severity, Meta-regression was used to investigate sources of heterogeneity.Results: Males had a significantly reduced risk for prevalent OA in the knee [Risk Ratio (RR) 0.63, 95% CI 0.53-0.75] and hand [RR 0.81, 95% CI 0.73-0.90] but not for other sites. Males aged < 55 years had a greater risk of prevalent cervical spine OA [RR 1.29, 95% CI 1.18-1.41]. Males also had significantly reduced rates of incident OA in the knee [Incidence Rate Ratio (IRR) 0.55, 95% CI 0.32-0.94] and hip [IRR 0.64, 95% CI 0.48-0.86], with a trend for hand [IRR 0.65, 95% confidence interval (CI) 0.35-1.20]. Females, particularly those >= 55 years, tended to have more severe OA in the knee but not other sites. Heterogeneity in the estimates of sex differences in prevalence was substantially explained by age and other study design factors including method of OA definition.Conclusions: The results demonstrate the presence of sex differences in OA prevalence and incidence, with females generally at a higher risk. Females also tend to have more severe knee OA, particularly after menopausal age. The site differences indicate the need for further studies to explore mechanisms underlying OA. (c) 2005 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.