Assessments of corneal endothelial cell density in growing children and its relationship to horizontal corneal diameter
Assessments of corneal endothelial cell density in growing children and its relationship to horizontal corneal diameter
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DOI：
10.1097/00006324-200212000-00008
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发表时间：
2002-12-01
影响因子：
1.4
通讯作者：
Doughty, MJ
中科院分区：
文献类型：
--
作者：
Müller, A;Doughty, MJ
在后方。很少有关于儿童角膜内皮细胞密度(ECD)的研究发表，特别是与年龄和角膜大小有关的研究。研究了角膜增大对内皮细胞的可能影响，并结合有关角膜直径和年龄的文献报道对结果进行了客观的回顾。方法：研究方法。119名5-15岁的儿童在使用非接触式镜面显微镜(Topcon SP-1000或SP-2000P)进行内皮摄影后，对ECD进行了评估，然后对细胞覆盖层进行了手动数字化。水平角膜直径作为可见虹膜直径，测量精度为0.5 mm。结果。使用所有单个细胞面积值计算的ECD的平均+/-SD值为3542+/-510个/mm(2)(范围为2576至5316)，而如果使用每个图像的平均细胞面积值来计算ECD，则为3246+/-416个/mm(2)(范围为2404至4817)。平均水平角膜直径为11.48±0.58 mm(+/-SD)。这组患者的角膜直径与年龄没有明显关系，但年龄较小的儿童的ECD值明显高于较大的儿童(p(2)，这取决于计算ECD的方法)。结论。在5-15岁的儿童中，ECD值与角膜直径显著相关，在比较研究中应考虑这一因素。
Backround. Few studies have been published of corneal endothelial cell density (ECD) in children, especially in relation to the age and corneal size of the individuals. The possible effect of corneal enlargement on the endothelium was studied, and the results were objectively reviewed in relation to literature reports on corneal diameter and age. Methods. ECD was assessed in 119 children aged 5 to 15 years after endothelial photography with a noncontact specular microscope (Topcon SP-1000 or SP-2000P), followed by manual digitization of cell overlays. The horizontal corneal diameter, as the visible iris diameter, was measured to 0.5-mm accuracy. Results. The mean +/- SD value for ECD, calculated using all individual cell area values, was 3542 +/- 510 cellS/mm(2) (range, 2576 to 5316), whereas it was 3246 +/- 416 cells/mm(2) (range, 2404 to 4817) if the mean cell area value from each image was used to calculate ECD. The mean horizontal corneal diameter was 11.48 +/- 0.58 mm (+/- SD). The corneal diameter was not obviously age-related for this group, but there were clear trends for younger children to have higher ECD values than older children (p(2), depending on the method for calculating ECD. Conclusions. ECD values were found to be significantly correlated to corneal diameter in children aged 5 to 15 years, and this factor should be considered in comparative studies.