A mechanistic model for internal bone remodeling exhibits different dynamic responses in disuse and overload
A mechanistic model for internal bone remodeling exhibits different dynamic responses in disuse and overload
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DOI：
10.1016/s0021-9290(00)00221-9
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发表时间：
2001-03-01
影响因子：
2.4
通讯作者：
Rodrigo, JJ
中科院分区：
文献类型：
--
作者：
Hazelwood, SJ;Martin, RB;Rodrigo, JJ
骨是一种动态组织，它通过成熟骨骼的骨重建过程，在正常功能过程中自我更新，并适应机械载荷。因此，重要的是要了解重塑对骨的力学功能的影响，以及重塑过程中固有的时间滞后的影响。在这项研究中，我们建立了一个骨重建的本构模型，该模型包括了一些相关的力学和生物学过程，并使用该模型来解决骨体积元素被废弃或过载时重建行为的差异。当元素被废弃时，重塑参数表现出衰减的振荡行为，振荡的幅度随着废弃程度的增加而增加。在超载情况下，重塑参数对超过阈值的载荷表现出严重的敏感行为。这些结果与实验结果有一定的对应关系，表明该模型在检验瞬变的重要性时可能是有用的。对废弃骨骼的反应，以及研究疲劳损伤移除在预防或导致应力性骨折中所起的作用。此外，本构算法目前正被用于骨适应的有限元模拟，以预测正常股骨内部结构的重要特征，以及研究骨疾病及其治疗。(C)2001爱思唯尔科学有限公司。保留所有权利。
Bone is a dynamic tissue which, through the process of bone remodeling in the mature skeleton, renews itself during normal function and adapts to mechanical loads. It is, therefore, important to understand the effect of remodeling on the mechanical function of bone, as well as the effect of the inherent time lag in the remodeling process. In this study, we develop a constitutive model for bone remodeling which includes a number of relevant mechanical and biological processes and use this model to address differences in the remodeling behavior as a volume element of bone is placed in disuse or overload. The remodeling parameters exhibited damped oscillatory behavior as the element was placed in disuse, with the amplitude of the oscillations increasing as the severity of disuse increased. In overload situations, the remodeling parameters exhibited critically sensitive behavior for loads beyond a threshold value. These results bear some correspondence to experimental findings, suggesting that the model may be useful when examining the importance of transient. responses for bone in disuse, and for investigating the role fatigue damage removal plays in preventing or causing stress fractures. In addition, the constitutive algorithm is currently being employed in finite element simulations of bone adaptation to predict important features of the internal structure of the normal femur, as well as to study bone diseases and their treatment. (C) 2001 Elsevier Science Ltd. All rights reserved.