Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography.
Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography.
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DOI：
10.1364/boe.6.003339
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发表时间：
2015-09
影响因子：
3.4
通讯作者：
Yang Zhao;Jason R. Maher;Jina Kim;M. Selim;H. Levinson;Adam Wax
中科院分区：
文献类型：
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作者：
Yang Zhao;Jason R. Maher;Jina Kim;M. Selim;H. Levinson;Adam Wax
烧伤的临床处理取决于对伤口深度的准确评估。目前的诊断方法主要依赖于主观的视觉检查，这可能会产生不同的结果。在这项研究中，光谱光学相干断层扫描被用来客观地评估烧伤在体内小鼠模型。观察到显著的光谱差异，并与组织病理学确定的损伤深度相关。这些结果的临床烧伤管理在人体组织的相关性进行了讨论。
Clinical management of burn injuries depends upon an accurate assessment of the depth of the wound. Current diagnostic methods rely primarily on subjective visual inspection, which can produce variable results. In this study, spectroscopic optical coherence tomography was used to objectively evaluate burn injuries in vivo in a mouse model. Significant spectral differences were observed and correlated with the depth of the injury as determined by histopathology. The relevance of these results to clinical burn management in human tissues is discussed.