Investigation on 'eighteen clashes' in clinical applications of medicine based on data mining
Investigation on 'eighteen clashes' in clinical applications of medicine based on data mining
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发表时间：
2015
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通讯作者：
Zuo Tin
中科院分区：
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作者：
Zuo Tin
目标：基于数据挖掘技术，探讨临床应用中“十八般”的形成规律，分析其配伍特点，为临床应用提供理论依据和警示作用。研究方法：收集了华中地区三甲中医医院的临床处方，运用关联规则挖掘方法分析了药物的配伍特征。结果如下：“十八般”临床应用结果显示，该院临床配伍的核心药物为板蓝根、半夏、附子、干姜、白术、茯苓等，半夏的使用频率高达75.88%。核心方剂为半夏-半夏、半夏-附子、附子-细辛、附子-干姜和半夏-干姜，其中半夏-附子的使用频率高达50.93%，占研究方剂的绝大部分。药物的核心成分为半夏-川乌-干姜、半夏-附子-甘草、半夏-黄芩、半夏-白术-甘草和半夏-党参-甘草，其中半夏-附子-甘草的利用率高达75.07%。结论：“十八冲”药物在临床上应用广泛，其配伍在方剂中的应用范围也很广，说明“十八冲”药物在临床上的应用是存在的，并不是最大的禁忌。
Objective: To investigate the formation rule of ‘eighteen clashes' in clinical applications based on data mining and analyze the compatible characteristics, in order to provide theoretical foundation and warning role for clinical application. Methods: The clinical prescriptions of top three traditional Chinese medicine hospitals in central China were gathered and the compatible characteristics of drugs was analyzed by using association rule mining. Results: The findings of ‘eighteen clashes' clinical application showed that the core drugs of clinical compatibility in the hospital were liquorice root, pinellia tuber, prepared common monkshood branched root, dried ginger, largehead atractylodes rhizome, indian bread and so on, and the utilization frequency of pinellia tuber reached up to 75.88%. The core medicine suits were liquorice root-pinellia tuber, pinellia tuber-prepared common monkshood branched root, prepared common monkshood branched root-liquorice root, liquorice root-dried ginger and pinellia tuber-dried ginger, and utilization frequency of pinellia tuber-prepared common monkshood branched root reached up to 50.93%, and accounted for most of all the research prescriptions. The core component of drugs were pinellia tuber-liquorice root-dried ginger, pinellia tuber-prepared common monkshood branched root-liquorice root, pinellia tuber-liquorice root-baical skullcap root, pinellia tube-largehead atractylodes rhizome-liquorice root and pinellia tube-tangshen-liquorice root, and the utilization frequency of pinellia tuber-prepared common monkshood branched root-liquorice root reached up to 75.07%. Conclusion: Drugs in ‘eighteen clashes' are widely used in clinical, and the applied range of compatibility of these drugs in prescriptions is also wide, which shows that the application of ‘eighteen clashes' do exist in clinical, and it is not the ultimate taboo.