New insights into atopic dermatitis: role of skin barrier and immune dysregulation.
New insights into atopic dermatitis: role of skin barrier and immune dysregulation.
复制标题
DOI：
10.2332/allergolint.13-rai-0564
复制
发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Leung DY
中科院分区：
文献类型：
--
作者：
Leung DY
特应性皮炎（AD）是一种慢性炎症性皮肤病，通常与食物过敏和哮喘的发生有关。对AD的新见解揭示了表皮结构异常的重要作用，导致上皮屏障渗漏以及慢性免疫激活，这有助于这种常见皮肤病的病理生理学。AD患者易受微生物定植或感染，最明显的是金黄色葡萄球菌和单纯疱疹病毒（HSV）。针对愈合和保护皮肤屏障以及控制免疫激活的措施是有效管理AD所必需的。早期干预可以改善AD的结局，并减少可能导致其他器官相关过敏性疾病的全身过敏原致敏。
Atopic dermatitis (AD) is a chronic inflammatory skin disease that is often associated with the development of food allergy and asthma. New insights into AD reveals an important role for structural abnormalities in the epidermis resulting in a leaky epithelial barrier as well as chronic immune activation that contribute to the pathophysiology of this common skin disease. Patients with AD have a predisposition to colonization or infection by microbial organisms, most notably Staphylococcus aureus and herpes simplex virus (HSV). Measures directed at healing and protecting the skin barrier and controlling the immune activation are needed for effective management of AD. Early intervention may improve outcomes for AD as well as reduce the systemic allergen sensitization that may lead to associated allergic diseases in other organs.