Cannabinoids as therapeutic agents in cancer: current status and future implications.
Cannabinoids as therapeutic agents in cancer: current status and future implications.
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DOI：
10.18632/oncotarget.2233
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发表时间：
2014-08-15
期刊：
影响因子：
--
通讯作者：
Ganju RK
中科院分区：
文献类型：
--
作者：
Chakravarti B;Ravi J;Ganju RK
大麻素的药理学重要性已被研究多年。大麻素由 (a) 大麻植物的活性化合物、(b) 内源性以及 (c) 合成大麻素组成。尽管大麻素在临床上用于抗姑息作用，但最近的研究开启了作为抗癌药物的有希望的可能性。它们已被证明在体外和体内不同癌症模型中具有抗增殖和抗血管生成作用。大麻素调节涉及细胞存活、侵袭、血管生成、转移等的关键细胞信号传导途径。人们更关注CB1和CB2，这两种大麻素受体被大多数大麻素激活。在这篇综述文章中，我们将重点关注广泛的大麻素，它们对各种癌症类型在生长、转移、能量代谢、免疫环境、干细胞性方面的受体依赖性和受体独立性功能作用，以及探索新的可能治疗机会的未来前景。
The pharmacological importance of cannabinoids has been in study for several years. Cannabinoids comprise of (a) the active compounds of the Cannabis sativa plant, (b) endogenous as well as (c) synthetic cannabinoids. Though cannabinoids are clinically used for anti-palliative effects, recent studies open a promising possibility as anti-cancer agents. They have been shown to possess anti-proliferative and anti-angiogenic effects in vitro as well as in vivo in different cancer models. Cannabinoids regulate key cell signaling pathways that are involved in cell survival, invasion, angiogenesis, metastasis, etc. There is more focus on CB1 and CB2, the two cannabinoid receptors which are activated by most of the cannabinoids. In this review article, we will focus on a broad range of cannabinoids, their receptor dependent and receptor independent functional roles against various cancer types with respect to growth, metastasis, energy metabolism, immune environment, stemness and future perspectives in exploring new possible therapeutic opportunities.
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影响因子：
4.8
作者：
Blázquez, C;Casanova, ML;Guzmán, M
通讯作者：
Guzmán, M
大麻素通过抑制 Akt 来减少 ErbB2 驱动的乳腺癌进展。
影响因子：
37.3
作者：
Caffarel, Maria M.;Andradas, Clara;Mira, Emilia;Perez-Gomez, Eduardo;Cerutti, Camilla;Moreno-Bueno, Gema;Flores, Juana M.;Garcia-Real, Isabel;Palacios, Jose;Manes, Santos;Guzman, Manuel;Sanchez, Cristina
通讯作者：
Sanchez, Cristina
影响因子：
50.3
作者：
Carracedo, A;Lorente, M;Velasco, G
通讯作者：
Velasco, G
影响因子：
11.2
作者：
Blazquez, Cristina;Salazar, Maria;Guzman, Manuel
通讯作者：
Guzman, Manuel
影响因子：
8
作者：
Caffarel, M. M.;Moreno-Bueno, G.;Sanchez, C.
通讯作者：
Sanchez, C.