Modulating Morphologies and Surface Properties of Nanoparticles from Cellulose-Grafted Bottlebrush Copolymers Using Complementary Hydrogen-Bonding between Nucleobases.
Modulating Morphologies and Surface Properties of Nanoparticles from Cellulose-Grafted Bottlebrush Copolymers Using Complementary Hydrogen-Bonding between Nucleobases.
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DOI：
10.1021/acs.biomac.9b01345
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发表时间：
2019-12
影响因子：
6.2
通讯作者：
Yangyang Yan;Chen Gao;Jianjun Li;Tao Zhang;Guang Yang;Zhongkai Wang;Zan Hua
中科院分区：
文献类型：
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作者：
Yangyang Yan;Chen Gao;Jianjun Li;Tao Zhang;Guang Yang;Zhongkai Wang;Zan Hua
在此，我们报道了一种以核碱基为疏水基团的纤维素接枝瓶刷共聚物的合成。通过溶剂开关法制备了该瓶刷共聚物的球形胶束。只有当引入具有互补核碱基功能的二嵌段共聚物时，才观察到从球体到蠕虫的形态转变。疏水相互作用不能引发形态转变，而与非均相丙烯酰胺核基单体的二嵌段共聚物在较高的A:T摩尔比下可以诱导形态转变，这可能是由弱氢键相互作用引起的。这种超分子“接枝”方法可以制备一系列形状和尺寸相似，但表面性质（如ζ电位）不同的纳米颗粒。此外，蠕虫状胶束和球体之间的可逆形态转变可以通过热响应聚合物的可逆坍缩和膨胀来实现。这项工作强调了互补核碱基之间的超分子“接枝”方法可以用来调整纳米粒子的形态和表面性质。
Herein, we report the synthesis of a cellulose-grafted bottlebrush copolymer with nucleobases as hydrophobic moieties. Well-defined spherical micelles from this bottlebrush copolymer were fabricated via a solvent switch method. A morphological transition from spheres to worms was only observed to occur when a diblock copolymer with a complementary nucleobase functionality was introduced. Hydrophobic interaction is not capable of triggering the morphological transformation and the diblock copolymer with the heterogeneous acrylamide nucleobase monomer can induce the morphological transition at higher A:T molar ratios, which might be caused by the weak H-bonding interaction. This supramolecular "grafting to" method enables the preparation of a series of nanoparticles with similar shapes and dimensions but distinct surface properties such as zeta potentials. Moreover, reversible morphological transitions between worm-like micelles and spheres can be achieved using a reversible collapsing and swelling of a thermo-responsive polymer. This work highlights that a supramolecular "grafting to" approach between complementary nucleobases can be utilized to tune morphologies and surface properties of nanoparticles.