The secretory pathway kinases.
The secretory pathway kinases.
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DOI：
10.1016/j.bbapap.2015.03.015
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发表时间：
2015-10
期刊：
影响因子：
--
通讯作者：
Tagliabracci VS
中科院分区：
文献类型：
--
作者：
Sreelatha A;Kinch LN;Tagliabracci VS
蛋白质磷酸化是一种几乎普遍的翻译后修饰，参与了大量的细胞事件。尽管已经观察到细胞外蛋白的磷酸化，但直到最近，磷酸化分泌蛋白的激酶的身份仍然是一个谜。基因组测序和遗传学研究的进展为发现一类定位于内质网、高尔基体和细胞外间隙内的新激酶铺平了道路。这些新的激酶磷酸化分泌途径中的蛋白质和蛋白聚糖，并似乎调节各种细胞外过程。这些激酶的突变导致人类疾病，从而强调了分泌途径中磷酸化的生物学重要性。
Protein phosphorylation is a nearly universal post-translation modification involved in a plethora of cellular events. Even though phosphorylation of extracellular proteins had been observed, the identity of the kinases that phosphorylate secreted proteins remained a mystery until recently. Advances in genome sequencing and genetic studies have paved the way for the discovery of a new class of kinases that localize within the endoplasmic reticulum, Golgi apparatus and the extracellular space. These novel kinases phosphorylate proteins and proteoglycans in the secretory pathway and appear to regulate various extracellular processes. Mutations in these kinases cause human disease, thus underscoring the biological importance of phosphorylation within the secretory pathway.