Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction
Experimental verification of proton beam monitoring in a human body by use of activity image of positron-emitting nuclei generated by nuclear fragmentation reaction
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DOI：
10.1007/s12194-007-0008-8
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发表时间：
2008-01-01
影响因子：
1.6
通讯作者：
Ogino, Takashi
中科院分区：
文献类型：
--
作者：
Nishio, Teiji;Miyatake, Aya;Ogino, Takashi
质子治疗是一种放射疗法，其通过使用扫描或调制的布拉格峰来实现肿瘤上的剂量集中。因此，准确评估质子照射体积非常重要。质子照射的体积可以通过使用PET设备检测来自正电子发射核的成对湮灭伽马射线来确认，所述正电子发射核通过入射质子在靶核上的核碎裂反应而产生。在质子束照射患者后，用PET-CT装置测量患者体内产生的正电子发射核的活性。对患有脑、头颈、肝、肺和骶骨肿瘤的患者进行活动测量。在CT图像上获得的3-D PET图像显示了与质子束照射区域的视觉对应。此外，确认了在每个照射部位获得的PET-CT图像的活动强度存在差异。比较从测量和基于反应截面的计算获得的活性值，并且确认了活性的强度和分布随着质子束照射后PET成像的开始时间而变化。正电子发射核的这一信息的临床应用对于促进未来更高精度的质子治疗非常重要。
Proton therapy is a form of radiotherapy that enables concentration of dose on a tumor by use of a scanned or modulated Bragg peak. Therefore, it is very important to evaluate the proton-irradiated volume accurately. The proton-irradiated volume can be confirmed by detection of pair-annihilation gamma rays from positron-emitting nuclei generated by the nuclear fragmentation reaction of the incident protons on target nuclei using a PET apparatus. The activity of the positron-emitting nuclei generated in a patient was measured with a PET-CT apparatus after proton beam irradiation of the patient. Activity measurement was performed in patients with tumors of the brain, head and neck, liver, lungs, and sacrum. The 3-D PET image obtained on the CT image showed the visual correspondence with the irradiation area of the proton beam. Moreover, it was confirmed that there were differences in the strength of activity from the PET-CT images obtained at each irradiation site. The values of activity obtained from both measurement and calculation based on the reaction cross section were compared, and it was confirmed that the intensity and the distribution of the activity changed with the start time of the PET imaging after proton beam irradiation. The clinical use of this information about the positron-emitting nuclei will be important for promoting proton treatment with higher accuracy in the future.