Comparison of recurrence patterns between 5 years and >5 years after curative operations in colorectal cancer patients
Comparison of recurrence patterns between 5 years and >5 years after curative operations in colorectal cancer patients
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DOI：
10.1002/jso.23349
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发表时间：
2013-07-01
影响因子：
2.5
通讯作者：
Kim, Jin Cheon
中科院分区：
文献类型：
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作者：
Seo, Seok In;Lim, Seok-Byung;Kim, Jin Cheon
背景和目的根据随访期（即根治性手术后5年和>5年）确定复发性结直肠癌的特征。其中835例结直肠癌根治性切除术后复发。复发发生在根治性手术后5年（n=799）或>5年（n=36）。比较两组之间的变量和复发模式。结果在835例复发患者中，术后5年以上复发率仅为4.3%。该组显示术前血清癌胚抗原水平较低，更多的肿瘤具有扩大生长，分化良好的组织学，且无淋巴结转移（均P <5年或5年，分别为（P=0.005）。在直肠癌患者中，复发模式显示了相同的结果。在结肠癌患者中，肝脏是两组中最常见的部位。结论经过5年的随访，常规监测检测其他恶性肿瘤似乎是足够的。但是，应考虑晚期（特别是晚期肺部）复发的可能性。放射学检查，以发现肺转移应考虑在后续计划。《肿瘤外科杂志》2013;108：9-13. (c)2013 Wiley Periodicals，Inc.
Background and Objectives To identify characteristics of recurrent colorectal cancer in terms of follow-up periods, that is, 5 years and >5 years after curative operations Methods This study enrolled 4,023 patients. Of them, 835 patients showed recurrence after primary curative resection for colorectal cancer. Recurrence occurred 5 years (n=799) or >5 years (n=36) after curative surgery. Variables and recurrence patterns were compared between the groups. Results Among the 835 patients who experienced recurrence, only 4.3% recurred >5 years after surgery. This group showed lower preoperative serum carcinoembryonic antigen levels, more tumors with expanding growth, well-differentiated histology, and no lymph node metastasis (all P5 years or 5 years, respectively (P=0.005). In rectal cancer patients, recurrence patterns revealed the same results. In colon cancer patients, the liver was the most prevalent site in both groups. Conclusions After 5 years of follow-up, routine surveillance for detecting other malignancies seems to be sufficient. However, the possibility of late (particularly late pulmonary) recurrence should be considered. Radiologic examination to detect pulmonary metastasis should be considered in the follow-up program. J. Surg. Oncol. 2013;108:9-13. (c) 2013 Wiley Periodicals, Inc.