Fecal Microbiota Transplantation Techniques, Applications, and Issues
Fecal Microbiota Transplantation Techniques, Applications, and Issues
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DOI：
10.1016/j.gtc.2012.08.008
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发表时间：
2012-12-01
影响因子：
3.7
通讯作者：
Campbell, Jordana
中科院分区：
文献类型：
--
作者：
Borody, Thomas Julius;Campbell, Jordana
鉴于最近艰难梭菌感染（CDI）的流行，粪便微生物群移植（FMT）获得了广泛的认可，每年造成近110，000人死亡。该手术的成功率引起了专家们的思考，哪些其他条件可能会受益。本文概述了（1）FMT的描述和历史，（2）CDI中的FMT出版物，（3）肠道微生物群作为虚拟器官的概念，（4）FMT使用的基本原理，（5）FMT在炎症性肠病中的应用，（6）新兴的FMT应用，（7）目前如何进行FMT，以及（8）未来如何进行FMT。
Fecal microbiota transplantation (FMT) has gained widespread recognition in light of the recent Clostridium difficile infection (CDI) epidemic, responsible for almost 110,000 deaths per year. The procedure's success rate has caused experts to reflect on what other conditions may benefit. This article provides an overview of (1) description and history of FMT, (2) FMT publications in CDI, (3) the concept of the gut microbiota as a virtual organ, (4) rationale for FMT use, (5) FMT use in inflammatory bowel disease, (6) emerging FMT applications, (7) how FMT is currently performed, and (8) how FMT may be performed in the future.