HIV and tuberculosis in Durban, South Africa: adherence to two medication regimens
HIV and tuberculosis in Durban, South Africa: adherence to two medication regimens
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DOI：
10.1080/09540120902729932
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发表时间：
2009-01-01
影响因子：
1.7
通讯作者：
Davis, Sheila M.
中科院分区：
文献类型：
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作者：
Corless, Inge B.;Wantland, Dean;Davis, Sheila M.
鉴于在资源有限的国家，抗逆转录病毒药物治疗的坚持率很高，问题是随着药物的广泛供应，坚持率是否会保持在这一水平。比较结核病（TB）药物的依从性，这已经很容易获得，抗逆转录病毒药物可能有助于表明未来可能坚持抗逆转录病毒药物，因为这些药物的获得变得更加普遍。本研究探讨了在南非德班的诊所接受结核病或人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）治疗的两个个体样本的连贯性、社会支持、症状状态、生活质量和药物依从性。调查结果显示，这两个群体的独特的社会经济背景。虽然有显着差异的心理变量，有两个样本在坚持服药以及坚持预约没有显着差异。鉴于这项研究的参与者是自我选择的，即那些能够到诊所就诊的人，以及那些可能坚持服用抗逆转录病毒药物的人，在解释这些发现时完全有理由谨慎。随着在南非越来越多地获得抗逆转录病毒药物，问题仍然是，鉴于获得粮食和其他基本必需品的限制，这种高坚持率是否会保持下去。
Given that antiretroviral (ARV) medication adherence has been shown to be high in resource-limited countries, the question remains as to whether adherence will remain at that level as medications become more widely available. Comparing adherence to tuberculosis (TB) medications, which have been readily available, and ARV medications may help to indicate the likely future adherence to ARVs as access to these medications becomes more widespread. This study examined sense of coherence, social support, symptom status, quality of life, and adherence to medications in two samples of individuals being treated either for TB or human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) at clinics in Durban, South Africa. Findings revealed the distinctive socio-economic backgrounds of the two cohorts. Although there were significant differences with regard to the psychosocial variables, there were no significant differences by the two samples in adherence to medications as well as adherence to appointments. Given the self-selected nature of the participants in this study, namely those able to attend clinic, as well as those likely to be adherent to ARVs, there is every reason for caution in the interpretations of these findings. As access to ARV medications becomes more widely available in South Africa, the question remains as to whether such high adherence will be maintained given the constraints of access to food and other basic necessities.