Sensory afferent neurotransmission in caudal nucleus tractus solitarius - Common denominators
Sensory afferent neurotransmission in caudal nucleus tractus solitarius - Common denominators
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DOI：
10.1093/chemse/21.3.387
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发表时间：
1996-06-01
期刊：
影响因子：
3.5
通讯作者：
Mendelowitz, D
中科院分区：
文献类型：
--
作者：
Andresen, MC;Mendelowitz, D
孤束核（NTS）接收广泛的感觉输入，包括味觉、胃肠道和心肺感觉输入，这些感觉输入在内脏上与亚核松散隔离。我们的实验室重点研究尾部 NTS (mNTS) 的背内侧区域，该区域对心血管反射至关重要。使用脑切片，我们主要研究由孤束刺激单突触激活的 mNTS 神经元，mNTS 神经元表现出不同程度的延迟兴奋、尖峰频率适应和超极化后。感觉传入传递是由作用于突触后非 NMDA 受体的谷氨酸介导的。谷氨酸的释放取决于至少四种不同的突触前钙通道，其中 N 型占主导地位。 NTS 中突触前钙通道的这种分布也存在于外周体细胞中，但在压力感受器感觉末梢中不存在。许多肽与这些感觉神经元相关，并且一些肽调节 mNTS 中的谷氨酸能传递。血管紧张素 II 通过突触前机制促进对感觉传入激活的兴奋反应。尾部 NTS 似乎具有与其他 NTS 区域相同的突触和细胞机制框架，并且肽可能在调节该框架中发挥关键作用。
The nucleus of the solitary tract (NTS) receives a wide range of sensory inputs including gustatory, gastrointestinal and cardiorespiratory which are loosely segregated viscerotopically to subnuclei. Our laboratory has focused on a dorsomedial area of caudal NTS (mNTS) which is critical for cardiovascular reflexes. Using a brainslice, we study primarily mNTS neurons mono-synaptically activated by solitary tract stimulation, mNTS neurons show varying degrees of delayed excitation, spike frequency adaptation and after hyperpolarizations. Sensory afferent transmission is mediated by glutamate acting at post-synaptic non-NMDA receptors. Glutamate release depends on at least four different presynaptic calcium channels with N-type predominating. This profile of presynaptic calcium channels in NTS is also present at the peripheral soma, but absent from the baroreceptor sensory endings. Many peptides are associated with these sensory neurons and several modulate glutamatergic transmission in mNTS. Angiotensin II facilitates excitatory responses to sensory afferent activation by a presynaptic mechanism. Caudal NTS appears to have a framework of synaptic and cellular mechanisms in common with other NTS areas and peptides may play a critical role modulating this framework.