Investigating gene-environment interaction in complex diseases: increasing power by selective sampling for environmental exposure
Investigating gene-environment interaction in complex diseases: increasing power by selective sampling for environmental exposure
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DOI：
10.1093/ije/dym215
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发表时间：
2007-12-01
影响因子：
7.7
通讯作者：
Ophoff, R. A.
中科院分区：
文献类型：
--
作者：
Boks, M. P. M.;Schipper, M.;Ophoff, R. A.
疾病相关等位基因对复杂疾病易感性的影响通常有限，这使得人们对环境与基因型的相互作用越来越感兴趣。然而，基因环境相互作用（GEI）并不容易研究，因为检测GEI需要大量的受试者。方法和结果本研究提供了一种潜在的有用方法，通过对环境暴露的选择性采样来增加这类研究的能力。我们表明，选择环境暴露的前10%和后10%可以导致基因分型所需受试者数量减少70%。结论本研究显示了选择性取样在基因与环境相互作用研究中的潜在作用。在基因分型广泛的研究中，如在全基因组筛选或在表型分型昂贵的研究中，所需受试者的减少可能特别有利。
Background The often limited influence of disease associated alleles on the vulnerability to complex diseases has lead to increased interest in environmental interaction with genotype. However, gene environmental interactions (GEIs) are not easily studied, since high numbers of subjects are required to detect GEI.Methods and results This study provides a potential useful method to increase the power of such studies through selective sampling for environmental exposure. We show that selecting the top and bottom 10% regarding environmental exposure can lead to a 70% reduction in the required number of subjects for genotyping.Conclusion This study demonstrates the potential usefulness of selective sampling in the study of the interplay between genes and environment. The reduction of required subjects can be particularly advantageous in studies where genotyping is extensive, such as in whole genome screens or in studies where phenotyping is expensive.