Development of an MR-compatible SPECT system (MRSPECT) for simultaneous data acquisition
Development of an MR-compatible SPECT system (MRSPECT) for simultaneous data acquisition
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DOI：
10.1088/0031-9155/55/6/002
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发表时间：
2010-03-21
影响因子：
3.5
通讯作者：
Nalcioglu, Orhan
中科院分区：
文献类型：
--
作者：
Hamamura, Mark J.;Ha, Seunghoon;Nalcioglu, Orhan
在医学成像中，单光子发射计算机断层扫描（SPECT）可以提供特定的功能信息，而磁共振成像（MRI）可以提供高空间分辨率的解剖信息以及互补的功能信息。在本研究中，我们开发了一种小型化的双模SPECT/MRI （MRSPECT）系统，并证明了同时采集SPECT和MRI数据的可行性，通过适当的组件缩放，可以实现全身MRSPECT系统。对于我们的MRSPECT系统，镉锌碲化（CZT）核辐射探测器与专用射频（RF）线圈连接，并放置在全身4t MRI系统中。各种幻像实验表征了SPECT和MRI硬件组件之间的相互作用。SPECT硬件的金属成分改变了B(0)场，并在MR图像的信噪比（SNR）中产生了不均匀的降低。磁场的存在在核投影数据中产生了位置偏移和分辨率损失。提出了各种技术来补偿这些不利影响。总的来说，我们的研究结果表明，准确、同时获取SPECT和MRI数据是可行的，这证明了MRSPECT通过使用适当的组件进一步发展用于小动物成像或全身人体系统。
In medical imaging, single-photon emission computed tomography (SPECT) can provide specific functional information while magnetic resonance imaging (MRI) can provide high spatial resolution anatomical information as well as complementary functional information. In this study, we developed a miniaturized dual-modality SPECT/MRI (MRSPECT) system and demonstrated the feasibility of simultaneous SPECT and MRI data acquisition, with the possibility of whole-body MRSPECT systems through suitable scaling of components. For our MRSPECT system, a cadmium-zinc-telluride (CZT) nuclear radiation detector was interfaced with a specialized radiofrequency (RF) coil and placed within a whole-body 4 T MRI system. Various phantom experiments characterized the interaction between the SPECT and MRI hardware components. The metallic components of the SPECT hardware altered the B(0) field and generated a non-uniform reduction in the signal-to-noise ratio (SNR) of the MR images. The presence of a magnetic field generated a position shift and resolution loss in the nuclear projection data. Various techniques were proposed to compensate for these adverse effects. Overall, our results demonstrate that accurate, simultaneous SPECT and MRI data acquisition is feasible, justifying the further development of MRSPECT for either small-animal imaging or whole-body human systems by using appropriate components.