Hypersomnolent and nonhypersomnolent patients with upper airway obstruction during sleep.
Hypersomnolent and nonhypersomnolent patients with upper airway obstruction during sleep.
复制标题
睡眠期间出现上呼吸道阻塞的嗜睡症和非嗜睡症患者。
作者：
W. Orr;R. Martin;R. Martin;N. Imes;N. Imes;R. Rogers;M. Stahl
当睡眠呼吸暂停和嗜睡综合征是由上呼吸道阻塞引起时，睡眠亢进被认为是与此类阻塞相关的睡眠剥夺的直接结果。这份报告的目的是描述一组四名无症状的受试者，他们在睡眠期间患有上呼吸道阻塞。这些受试者与一组患有睡眠呼吸暂停和睡眠过度综合征的患者配对。有症状组和无症状组在上呼吸道阻塞的绝对数(252比231)、平均持续时间(20.8比25.9秒)、平均动脉二氧化碳分压(39比39 mm Hg)和睡眠脑电模式等方面均无显著差异。两组间唯一有显著差异的变量是有症状的患者的体重(128vs90 kg；P<0.002)、清醒时的低动脉血氧分压(54vs80 mm Hg；P<0.002)和睡眠时的低PaO2(47vs70 mm Hg；P<0.01)。根据这些数据，我们得出结论，睡眠呼吸暂停患者由于上呼吸道阻塞而出现的睡眠亢进不能用剥夺睡眠来解释，其他因素需要在未来的研究中仔细检查。
When the syndrome consisting of sleep-induced apnea and hypersomnolence is due to upper airway obstruction, the hypersomnolence is believed to be the direct result of deprivation of sleep related to such obstructions. The purpose of this report is to describe a group of four asymptomatic subjects with upper airway obstruction during sleep. These subjects were matched with a group of patients with the syndrome of sleep-induced apnea and hypersomnolence. There were no significant differences between symptomatic and asymptomatic groups in terms of the absolute number of upper airway obstructions (252 vs 231), their mean duration (20.8 vs 25.9 seconds), the mean arterial carbon dioxide tension during sleep (39 vs 39 mm Hg), or the electroencephalographic patterns during sleep. The only variables that emerged as significantly different between the two groups were the weights (128 vs 90 kg; P less than 0.05), the low arterial oxygen pressure (PaO2) on waking (54 vs 80 mm Hg; P less than 0.002), and the lower PaO2 during sleep (47 vs 70 mm Hg; P less than 0.01) in the symptomatic patients. From these data, we conclude that the hypersomnolence in patients with sleep-induced apnea due to upper airway obstruction cannot be explained by deprivation of sleep, and other factors need to be carefully examined in future studies.