Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis
Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis
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DOI：
10.1016/s0140-6736(10)60235-8
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发表时间：
2010-03-13
期刊：
影响因子：
168.9
通讯作者：
Rothwell, Peter M.
中科院分区：
文献类型：
--
作者：
Webb, Alastair J. S.;Fischer, Urs;Rothwell, Peter M.
不同类别的抗高血压药物在预防卒中方面的有效性存在无法解释的差异，这可能是由于血压个体内变异性的类别效应。我们进行了一项系统回顾，以评估随机对照试验中的任何此类影响。方法从试验报告中提取收缩压（SBP）平均值（SD）的基线和随访数据。治疗对血压个体间方差（SD 2）（个体内变异性的替代）的影响，表示为方差比（VR），与对临床结局的影响相关。结果平均（SD）收缩压在后续的1372个合格的试验中，389（28%）。VR试验之间存在显著异质性（p
Introduction Unexplained differences between classes of antihypertensive drugs in their effectiveness in preventing stroke might be due to Class effects on intraindividual variability in blood pressure. We did a systematic review to assess any such effects in randomised controlled trials.Methods Baseline and follow-up data for mean (SD) of systolic blood pressure (SBP) were extracted from trial reports. Effect of treatment on interindividual variance (SD2) in blood pressure (a surrogate for within-individual variability), expressed as the ratio of the variances (VR), was related to effects on clinical outcomes. Pooled estimates were derived by use of random-effects meta-analysis.Findings Mean (SD) SBP at follow-up was reported in 389 (28%) of 1372 eligible trials. There was substantial heterogeneity between trials in VR (p