Background selection and patterns of genetic diversity in Drosophila melanogaster
Background selection and patterns of genetic diversity in Drosophila melanogaster
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DOI：
10.1017/s0016672300034029
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发表时间：
1996-10-01
影响因子：
1.5
通讯作者：
Charlesworth, B
中科院分区：
文献类型：
--
作者：
Charlesworth, B
针对有害突变的选择对连锁中性位点变异（背景选择）的影响的理论模型被用来预测果蝇染色体位置与DNA水平遗传变异之间的关系。的突变，选择和重组参数的变化，他们所依据的预测的灵敏度进行检查。结果表明，染色体定位与D.黑腹果蝇的遗传多样性可以用背景选择来解释，特别是如果考虑到作用于转座因子的弱选择力的话。特别是，在X染色体的远端部分的多样性的梯度，和缺乏多样性的4号染色体和在主要染色体的基础上，可以充分占。然而，在D.黑腹，这可能反映了除背景选择以外的其他力量的影响。
Theoretical models of the effects of selection against deleterious mutations on variation at linked neutral sites (background selection) are used to predict the relations between chromosomal location and genetic variability at the DNA level, in Drosophila melanogaster. The sensitivity of the predictions to variation in the mutation, selection and recombination parameters on which they are based is examined. It is shown that many features of the observed relations between chromosomal location and level of genetic diversity in D. melanogaster can be explained by background selection, especially if the weak selective forces acting on transposable elements are taken into account. In particular, the gradient in diversity in the distal portion of the X chromosome, and the lack of diversity on chromosome 4 and at the bases of the major chromosomes, can be fully accounted for. There are, however, discrepancies between predicted and observed values for some loci in D. melanogaster, which may reflect the effects of forces other than background selection.