Sabotaging the protein factory to overcome glioma stem cell resistance.
Sabotaging the protein factory to overcome glioma stem cell resistance.
复制标题
破坏蛋白质工厂以克服神经胶质瘤干细胞的抵抗力。
DOI：
10.1093/neuonc/noad090
复制
发表时间：
2023
期刊：
影响因子：
15.9
通讯作者：
Castro,MariaG
中科院分区：
文献类型：
--
作者：
Haase,Santiago;Lowenstein,PedroR;Castro,MariaG
社论1442优雅的实验设计，导致了NIR的功能的非常详细的表征，这无疑将有助于设计定制的疗法来调节所描述的机制NIR在GSC中的作用的比较，非干肿瘤细胞和NPC是证明rDNA转录在GSC中的重要性的关键。这项工作为新的问题开辟了前景，例如哪些机制介导NIR增加这些机制是否可以被表观遗传学靶向，或者NIR表达是否在某些GBM亚型中占优势。此外，这项工作的发现鼓励了近红外药理学抑制剂的发展。
Editorial 1442 elegant experimental design that led to a very detailed characterization of the function of NIR, which will undoubtedly help to design tailored therapies to modulate the described mechanisms The comparison of the role of NIR in GSCs, non-stem tumor cells and NPCs was pivotal to demonstrate the importance of rDNA transcription in GSCs.This work opens the perspective to new questions such as which mechanisms mediate NIR increased expression in GSCs and whether these mechanisms can be epigenetically targeted, or whether NIR expression is preponderant in certain GBM subtypes. Additionally, the development of NIR pharmacological inhibitors is encouraged by the findings in this work.