BREUER-HERING INFLATION REFLEX AND BREATHING PATTERN IN ANESTHETIZED HUMANS AND CATS
BREUER-HERING INFLATION REFLEX AND BREATHING PATTERN IN ANESTHETIZED HUMANS AND CATS
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DOI：
10.1152/jappl.1981.51.5.1162
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发表时间：
1981-01-01
影响因子：
3.3
通讯作者：
GAUDY, JH
中科院分区：
文献类型：
--
作者：
GAUTIER, H;BONORA, M;GAUDY, JH
在用阿法沙酮麻醉的9只猫和9个人中，在吸气末或呼气末气道阻塞之前和期间记录呼吸活动和气管压力。还在呼气末进行了肺充气。在高碳酸血症期间也分析了呼吸模式。吸气或充气结束时的阻塞引起猫和人的呼吸暂停。伴随着高碳酸血症期间潮气量的增加，猫的吸气持续时间减少，而人类则没有变化。显然，在充气过程中延迟吸气开始的布鲁尔-赫林反射在猫和人身上同样有效。布洛伊尔-赫林阈值曲线（Breuer-Hering threshold curve）解释了灵感的关闭，猫和人的阈值曲线不同。Breuer-Hearing充气反射在人类中是有效的，但在高碳酸血症导致的呼吸活动增加期间，它似乎不参与吸气关闭开关机制的控制。
In 9 cats and 9 humans anesthetized with alfaxalone, respiratory activity and tracheal pressure were recorded prior to and during occlusion of the airway at end inspiration or end expiration. Lung inflations at the end of expiration were also performed. The ventilatory pattern was also analyzed during hypercapnia. Occlusions at the end of inspiration or inflations provoked an apnea in cats and humans. Concomitant with increases in tidal volume during hypercapnia, inspiratory duration decreased in cats and did not change in humans. Apparently, the Breuer-Hering reflex, which delays the onset of inspiration during inflation, was equally operative in cats and humans. The Breuer-Hering threshold curve, which accounts for the off-switch of inspiration, was different in cats and humans. The Breuer-Hearing inflation reflex is operative in humans but it does not seem to be involved in the control of the inspiratory off-switch mechanisms during increased respiratory activity resulting from hypercapnia.