Pre-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide
Pre-metalation structural insights into the use of alkali-metal-mediated zincation for directed ortho-metalation of a tertiary aromatic amide
复制标题
DOI：
10.1002/anie.200503202
复制
发表时间：
2006-01-01
影响因子：
16.6
通讯作者：
Mulvey, RE
中科院分区：
文献类型：
--
作者：
Clegg, W;Dale, SH;Mulvey, RE
捕食者在[{(iPr) 2NC (Ph)(O)} Li (μ-tmp)(μ-tBu) Zn (tBu)]结构中与猎物相遇，揭示了在锌酸盐吞噬（邻锌化）酰胺之前存在的芳族酰胺-碱金属锌酸盐“预配合物”的定向正金属化（DoM）。Tmp = 2,2,6,6 -四甲基哌啶酯。
The predator meets its prey in the structure of [{(iPr) 2NC (Ph)(O)} Li (μ-tmp)(μ-tBu) Zn (tBu)] which reveals an aromatic amide–alkali metal zincate “precomplex” for directed ortho-metalation (DoM) that exists prior to the devouring (ortho-zincation) of the amide by the zincate. tmp= 2, 2, 6, 6-tetramethylpiperidide.