Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats
Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats
复制标题
正常与自发性高血压大鼠肠原位循环灌注杜仲提取物七种活性成分吸收动力学比较
DOI：
10.1002/bmc.4714
复制
发表时间：
2019-11-19
影响因子：
1.8
通讯作者：
Gong, Zipeng
中科院分区：
文献类型：
--
作者：
Hu, Hejia;Wu, Linlin;Gong, Zipeng
杜仲。杜仲（E. ulmoides）是一种有价值的滋补中药，在中国已被用于治疗高血压。鉴于大多数中药主要用于治疗疾病，研究中药在病理状态下的药代动力学比在正常状态下更有用。然而，杜仲提取物有效成分的吸收动力学在病理和生理条件下的差异尚未见报道。因此，本研究采用大鼠肠道原位循环灌注模型，研究杜尔杜德提取物中七种有效成分(genipinic酸、原儿茶酸、新绿原酸、绿原酸、隐绿原酸、（+)-松脂醇二o - β - d -葡萄糖苷和(+)-松脂醇4′- o - β - d -葡萄糖苷）在正常和自发性高血压大鼠体内的吸收动力学差异。本研究结果提示自发性高血压的病理状态可能改变杜仲提取物有效成分的吸收，为提高杜仲在临床的合理使用提供参考。
Eucommia ulmoides Oliv. (E. ulmoides) is a valuable and nourishing medicinal herb in China that has been used in the treatment of hypertension. Given the fact that most traditional Chinese medicine is mainly used to treat disease, investigating the pharmacokinetics of traditional Chinese medicines in the pathological state is more useful than that in the normal state. However, the differences in the absorption kinetics of active ingredients of E. ulmoides extract between pathological and physiological conditions have not been reported. Therefore, in this study, the rat intestinal in situ circulatory perfusion model was used to investigate the differences in absorption kinetics of seven active ingredients of E. ulmoides extract in normal and spontaneously hypertensive rats, namely, genipinic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, (+)-pinoresinol di-O-beta-D-glucopyranoside and (+)-pinoresinol 4 '-O-beta-D-glucopyranoside. Our results indicate that the pathological state of spontaneous hypertension may change the absorption of active components of E. ulmoides extracts, and these findings may provide a reference for improving the rational use of E. ulmoides in the clinic.