Adaptive modification of saccade amplitude in Parkinson's disease
Adaptive modification of saccade amplitude in Parkinson's disease
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DOI：
10.1093/brain/awf168
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发表时间：
2002-07-01
期刊：
影响因子：
14.5
通讯作者：
Jones, RD
中科院分区：
文献类型：
--
作者：
MacAskill, MR;Anderson, TJ;Jones, RD
扫视（快速眼球运动）的准确性随着时间的推移而保持，并且是通常归因于小脑的适应能力。在某些任务中，适应可能发生在其他地方，例如在记忆引导的扫视中的前额皮质。我们假设记忆引导的扫视适应在帕金森病中会受损，因为基底神经节功能障碍会破坏前额叶皮层的运作，而视觉引导的扫视适应将被保留。适应是通过持续但不易察觉地移动目标来诱导的，因为向它们进行扫视，导致人为扫视不准确。12名帕金森病受试者（关闭药物治疗）和12名年龄匹配的对照组在单独的会议上进行了245次视觉和记忆引导的水平扫视。红外线眼动仪检测到的扫视，在此期间，目标是由12.5%的初始跳跃的大小，无论是在相同的（离心）或相反的（向心）方向。帕金森病患者的视觉引导扫视比对照组小[F（1，20）= 9.10，P < 0.01]，但两组都适当地改变了扫视的大小。帕金森病患者的记忆引导性眼跳也小于对照组[F（1，19）= 5.93，P < 0.05]。对照组适当地减少（8.6%）或增加（4.1%）这些扫视的大小，帕金森病受试者减少扫视的大小，以响应向心适应（过度18.3%）和离心适应（3.5%）。帕金森氏病受试者不太能够适当地修改扫视的大小时，指定的运动大小在运动记忆：过度hypometria的偏好被调用，无论适应方向。这表明，在某些任务中，扫视适应涉及小脑以外的结构。
The accuracy of saccades (fast eye movements) is maintained over time and is an adaptive ability usually ascribed to the cerebellum. Adaptation might occur elsewhere in certain tasks, such as in the prefrontal cortex for memory-guided saccades. We hypothesized that adaptation of memory-guided saccades would be impaired in Parkinson's disease, as basal ganglia dysfunction can disrupt the operation of the prefrontal cortex, while adaptation of visually guided saccades would be preserved. Adaptation was induced by consistently yet imperceptibly displacing targets as saccades were made toward them, causing artificial saccadic inaccuracy. Twelve Parkinson's disease subjects (OFF medication) and 12 age-matched controls performed 245 visually- and memory-guided horizontal saccades in separate sessions. An infrared eye tracker detected the saccade, during which the target was displaced by 12.5% of the size of the initial jump, either in the same (centrifugal) or the opposite (centripetal) direction. Parkinson's disease subjects made smaller visually guided saccades than did controls [F(1,20) = 9.10, P < 0.01], yet both groups modified saccade size appropriately. Parkinson's disease memory-guided saccades were also smaller than those of controls [F(1,19) = 5.93, P < 0.05]. While controls decreased (by 8.6%) or increased (by 4.1%) the size of these saccades appropriately, Parkinson's disease subjects decreased saccade size in response to both centripetal adaptation (by an excessive 18.3%) and centrifugal adaptation (by 3.5%). Parkinson's disease subjects were less able to modify saccadic size appropriately when the movement size was specified in motor memory: a predilection for excessive hypometria was invoked, regardless of adaptation direction. This indicates that, in certain tasks, saccadic adaptation involves structures other than the cerebellum.