Antibiotic susceptibility pattern of rapidly growing mycobacteria
Antibiotic susceptibility pattern of rapidly growing mycobacteria
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DOI：
10.4103/0022-3859.65278
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发表时间：
2010-04-01
影响因子：
1.6
通讯作者：
Madhavan, H. N.
中科院分区：
文献类型：
--
作者：
Gayathri, R.;Therese, Lily K.;Madhavan, H. N.
背景资料：引起人类感染的快速生长分枝杆菌（RGM）主要包括偶发分枝杆菌群、分枝杆菌属和龟分枝杆菌。抗生素敏感性测试对于确定适当的治疗是重要的，因为用于治疗RGM的抗生素不同于用于治疗由分枝杆菌缓慢生长引起的感染的抗生素。目的：采用Kirby Bauer法并遵循临床和实验室标准化研究所（CLSI）指南确定RGM的抗生素敏感性。设置和设计：Larsen和Toubro微生物学研究中心，视觉研究基金会，Sankara Nethralaya，钦奈，回顾性研究。材料与方法：按照CLSI方法对药物阿米卡星、阿奇霉素、妥布霉素、头孢他啶、头孢噻肟、头孢呋辛、头孢哌酮、头孢曲松、环丙沙星、氧氟沙星、诺氟沙星、加替沙星和莫西沙星进行抗生素敏感性试验。结果和结论：148株RGM中，146株（98株）对阿米卡星敏感，138株（91株）对加替沙星敏感，132株（87株）对阿替沙星敏感，122株（76株）对环丙沙星敏感，116株（74株）对诺氟沙星敏感。大多数RGM对头孢他啶、头孢噻肟和头孢哌酮耐药。所有的M。分离株对妥布霉素耐药。纸片扩散法体外药敏试验结果显示，大多数RGM对阿米卡星敏感，其次为加替沙星、莫西沙星和环丙沙星。
Background : The rapidly growing mycobacteria (RGM) causing human infections primarily consist of the Mycobacterium fortuitum group, Mycobacterium abscessus and Mycobacterium chelonae. The antibiotic susceptibility testing is important to determine the appropriate therapy as the antibiotics used to treat RGM are different from those used for treating infections caused by slow growers of mycobacteria. Aim : To determine antibiotic susceptibility of RGM using Kirby Bauer method and following Clinical and Laboratory Standards Institute (CLSI) guidelines. Settings and Design : Larsen and Toubro Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Retrospective study. Materials and Methods : The antibiotic susceptibility testing was performed following CLSI method for the drugs Amikacin, Azithromycin, Tobramycin, Ceftazidime, Cephotaxime, Cefuroxime, Cefaperazone, Ceftriaxone, Ciprofloxacin, Ofloxacin, Norfloxacin, Gatifloxacin and Moxifloxacin. Results and Conclusions : Out of the 148 RGM isolates 146 (98) were susceptible to amikacin, 138 (91) to gatifloxacin, 132 (87) to moxifloxacin, 122 (76) to ciprofloxacin and 116 (74) to Norfloxacin. Majority of the RGM were resistant to Ceftazidime, Cephotaxime and Cefaperazone. All the M. abscessus isolates were resistant to tobramycin. The in vitro antibiotic susceptibility testing by disc diffusion method showed that majority of the RGM were sensitive to Amikacin followed by Gatifloxacin, Moxifloxacin and Ciprofloxacin.