Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus
Voxel-based analysis of gray matter and CSF space in idiopathic normal pressure hydrocephalus
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DOI：
10.1159/000119521
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Ishii, Kazunari;Kawaguchi, Tetsuro;Mori, Etsuro
目的：采用基于体素的形态测量学，研究基于INPH指南诊断的特发性正常压力脑积水（INPH）的局部形态学变化。方法：三维磁共振成像进行了34 INPH患者，谁符合可能的INPH标准，可能34阿尔茨海默病患者，和34名正常对照组。结果如下：使用统计参数映射对形态学数据进行基于体素的形态测量学分析，显示脑室和侧裂扩大以及高度凸性的狭窄沟，尤其是在INPH组的楔前叶中，在小脑、尾状核和丘脑中灰质密度降低。结论：在INPH中，形态学改变发生在额顶高凸，心室扩张，侧裂扩张和内侧顶叶沟狭窄。版权所有（C）2008 S. Karger AG，巴塞尔。
Aims: To investigate regional morphologic changes in idiopathic normal pressure hydrocephalus (INPH) based on diagnosis with INPH Guidelines using voxel-based morphometry. Method: Three-dimensional magnetic resonance imaging was performed in 34 INPH patients, who met probable INPH criteria, probable 34 Alzheimer disease patients, and 34 normal control subjects. Results: Statistical parametric mapping was used to conduct voxel-based morphometry analysis of the morphologic data and revealed enlarged ventricles and sylvian fissures and stenotic sulci of high convexity, especially in the precuneus in the INPH group, with decreased gray matter density in the insula, caudate and thalamus. Conclusion: In INPH, morphologic change occurs in the frontoparietal high convexity with ventricular dilatations, dilated sylvian fissures and tight sulci in the medial parietal lobes. Copyright (C) 2008 S. Karger AG, Basel.