Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin
Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin
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DOI：
10.1016/j.jep.2006.02.021
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发表时间：
2006-09-19
影响因子：
5.4
通讯作者：
Yesilada, Erdem
中科院分区：
文献类型：
--
作者：
Kupeli, Esra;Orhan, Ilkay;Yesilada, Erdem
本文报道了从苹果Maclura pomifera（Rafin.）Schneider，研究了它们的体内抗炎和抗伤害活性。对于抗炎活性，使用角叉菜胶诱导的后爪水肿和12-O-十四酰基-13-乙酸酯（TPA）诱导的小鼠耳水肿模型，并且对于抗伤害感受活性，使用对苯醌诱导的腹部收缩试验。结果表明，斯堪的纳维亚酮、氯仿和乙醇提取物在100 mg/kg剂量下对角叉菜胶诱导的后爪肿胀模型具有抗伤害活性和抗炎活性。还发现相同的化合物和提取物在（TPA）诱导的小鼠耳水肿模型中具有高活性，而耳拉星和H2O提取物在所有测定中显示无活性。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
The aqueous, ethanolic and chloroform extracts and two prenylated isoflavones: scandenone (I) and auriculasin (II), isolated from the fruits of Maclura pomifera (Rafin.) Schneider, were investigated for their in vivo anti-inflammatory and antinociceptive activity. For the anti-inflammatory activity, both carrageenan-induced hind paw edema and 12-O-tetradecanoyl-13-acetate (TPA)-induced mouse ear edema models and for the antinociceptive activity, p-benzoquinone-induced abdominal constriction test were used. Scandenone, the chloroform and the ethanolic extracts were shown to possess antinociceptive activity and anti-inflammatory activity on carrageenan-induced hind paw edema model at 100 mg/kg dose. The same compound and the extract were also found to be highly active in (TPA)-induced mouse ear edema model whereas auriculasin and the H2O extract showed to be inactive in all of the assays. (c) 2006 Elsevier Ireland Ltd. All rights reserved.