Phytoestrogens: the "natural" selective estrogen receptor modulators?
Phytoestrogens: the "natural" selective estrogen receptor modulators?
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DOI：
10.1016/s0301-2115(98)00281-4
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发表时间：
1999-07-01
影响因子：
2.6
通讯作者：
Debi, A
中科院分区：
文献类型：
--
作者：
Brzezinski, A;Debi, A
植物雌激素是存在于人类食用的几种植物中的双酚类化合物。蚕豆和亚麻籽是植物雌激素特别丰富的来源。当以相对大量摄入时，植物雌激素已被证明在动物和人类中具有显著的雌激素激动剂/拮抗剂作用。流行病学、实验室和临床证据表明，植物雌激素与某些选择性雌激素受体调节剂一样，对乳房具有抗增殖作用，并对脂蛋白谱和骨密度产生积极影响。它们也可能改善一些更年期症状。这一证据进行了严格审查，并讨论了富含植物雌激素的食物对妇女健康的饮食干预可能带来的好处。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
Phytoestrogens are diphenolic compounds that are present in several plants eaten by human beings. Soybeans and flaxseed are particularly abundant source of phytoestrogens. When ingested in relatively large amounts, phytoestrogens have been shown to have significant estrogen agonists/antagonists effects in animals and humans. There is epidemiological, laboratory and clinical evidence which indicates that phytoestrogens, like certain selective estrogen receptor mudulators, have an antiproliferative effect on the breast, and positive effects on the lipoprotein profile and bone density. They might also improve some of the climacteric symptoms. This evidence is critically reviewed, and the possible benefit of dietary intervention with phytoestrogen-rich food for woman's health is discussed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.