Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission
Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission
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DOI：
10.1016/j.vetpar.2011.04.018
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发表时间：
2011-09-08
影响因子：
2.6
通讯作者：
Blouin, Edmour F.
中科院分区：
文献类型：
--
作者：
de la Fuente, Jose;Moreno-Cid, Juan A.;Blouin, Edmour F.
由节肢动物传播的病原体引起的疾病极大地影响着人和动物的健康。最近的研究提供了证据表明，扁虱保护性抗原可以用于疫苗的开发，其双重目标是控制节肢动物的感染和减少它们对病原体的媒介能力。在此综述中，保护性抗原，如亚油酸/阿基蛋白，在媒介物种中高度保守，显示出在开发控制节肢动物侵染和减少病原体传播的通用疫苗方面的前景。然而，为了实现这一目标，还需要在关键领域进行进一步研究。(C)2011爱思唯尔B.V.保留所有权利。
Diseases caused by arthropod-borne pathogens greatly impact on human and animal health. Recent research has provided evidence that tick protective antigens can be used for development of vaccines with the dual target of controlling arthropod infestations and reducing their vector capacity for pathogens. As reviewed herein, protective antigens such as subolesin/akirin, which are highly conserved across vector species, show promise for use in development of a universal vaccine for the control of arthropod infestations and the reduction of pathogen transmission. However, further research is needed in critical areas towards achieving this goal. (C) 2011 Elsevier B.V. All rights reserved.