Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer.
复制标题
DOI：
10.1038/onc.2009.358
复制
发表时间：
2010-01-21
期刊：
影响因子：
8
通讯作者：
Cheng, T.
中科院分区：
文献类型：
--
作者：
DeBerardinis, R. J.;Cheng, T.
几十年的研究一直在寻求肿瘤细胞代谢的特征，希望利用肿瘤特异性活动来治疗癌症。起源于Warburg对肿瘤细胞中有氧糖酵解的开创性观察，大多数注意力集中在葡萄糖代谢上。然而，自20世纪50年代以来，癌症生物学家也认识到谷氨酰胺(Q)作为肿瘤营养物质的重要性。谷氨酰胺基本上参与了肿瘤细胞增殖的每一个核心代谢任务：它参与生物能量学，支持细胞防御氧化应激，并在大分子的产生中补充葡萄糖代谢。最近的研究发现，c-myc控制谷氨酰胺的摄取和降解，谷氨酰胺本身对一些促进肿瘤生长的信号通路施加影响，这进一步提高了人们对谷氨酰胺代谢的兴趣。这些观察结果促使人们重新努力了解谷氨酰胺在肿瘤中的代谢调节，并制定针对谷氨酰胺在癌症中的代谢的策略。在这里，我们回顾了谷氨酰胺在癌症中的蛋白质作用，包括直接支持肿瘤生长和介导肿瘤进展特征的全身代谢的一些复杂影响。
Several decades of research have sought to characterize tumor cell metabolism in the hopes that tumor-specific activities can be exploited to treat cancer. Having originated from Warburg's seminal observation of aerobic glycolysis in tumor cells, most of this attention has focused on glucose metabolism. However, since the 1950s cancer biologists have also recognized the importance of glutamine (Q) as a tumor nutrient. Glutamine contributes to essentially every core metabolic task of proliferating tumor cells: it participates in bioenergetics, supports cell defenses against oxidative stress, and complements glucose metabolism in the production of macromolecules. Interest in glutamine metabolism has been heightened further by the recent findings that c-myc controls glutamine uptake and degradation, and that glutamine itself exerts influence over a number of signaling pathways that contribute to tumor growth. These observations are stimulating a renewed effort to understand the regulation of glutamine metabolism in tumors and to develop strategies to target glutamine metabolism in cancer. Here we review the protean roles of glutamine in cancer, both in the direct support of tumor growth and in mediating some of the complex effects on whole-body metabolism that are characteristic of tumor progression.
登录
查看更多内容
影响因子：
56.9
作者：
FLIER, JS;MUECKLER, MM;LODISH, HF
通讯作者：
LODISH, HF
影响因子：
11.2
作者：
Bobrovnikova-Marjon, EV;Marjon, PL;Abcouwer, SF
通讯作者：
Abcouwer, SF
DOI：
10.1097/gim.0b013e31818b0d9b
发表时间：
2008-11
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
DeBerardinis RJ
通讯作者：
DeBerardinis RJ
影响因子：
4
作者：
Donadio, Ana C.;Lobo, Carolina;Segura, Juan A.
通讯作者：
Segura, Juan A.
影响因子：
4.1
作者：
BRAND, K
通讯作者：
BRAND, K