Amelioration of improper differentiation of somatostatin-positive interneurons by triiodothyronine in a growth-retarded hypothyroid mouse strain.
Amelioration of improper differentiation of somatostatin-positive interneurons by triiodothyronine in a growth-retarded hypothyroid mouse strain.
复制标题
三碘甲状腺原氨酸改善生长迟缓的甲状腺功能减退小鼠品系中生长抑素阳性中间神经元的不当分化。
DOI：
10.1016/j.neulet.2013.11.052
复制
发表时间：
2014
影响因子：
2.5
通讯作者：
Itoi K.
中科院分区：
文献类型：
--
作者：
Uchida K;Taguchi Y;Sato C;Miyazaki H;Kobayashi K;Kobayashi T;Itoi K.
甲状腺激素（TH）在大脑发育中起着重要作用，在怀孕期间或出生后早期缺乏TH会导致神经系统疾病，如克汀病。甲状腺功能减退减少了新皮层和海马中小清蛋白（PV）阳性中间神经元的数量。在这里，我们使用的小鼠品系（生长迟缓; grt），显示生长迟缓和甲状腺功能减退症，以检查是否生长抑素（Sst）阳性的中间神经元，从相同的池的神经祖细胞PV阳性细胞也被改变TH缺乏症。与正常对照组小鼠相比，grt小鼠新皮层和海马PV阳性中间神经元数量显著减少。相反，PV神经元的数量减少，Sst阳性的中间神经元在grt小鼠的海马和门的齿状回的层oriens的数量增加，虽然他们的数量是不变的新皮层。这些变化被逆转的三碘甲状腺原氨酸管理从出生后第0天（PD）至20。然而，在PD 21后开始的TH补充并不影响PV或Sst阳性细胞的数量。这些结果表明，在出生后的前三周，TH可能是至关重要的中间神经元亚群的产生。
Thyroid hormone (TH) plays an important role in brain development, and TH deficiency during pregnancy or early postnatal periods leads to neurological disorders such as cretinism. Hypothyroidism reduces the number of parvalbumin (PV)-positive interneurons in the neocortex and hippocampus. Here we used a mouse strain (growth-retarded; grt) that shows growth retardation and hypothyroidism to examine whether somatostatin (Sst)-positive interneurons that are generated from the same pool of neural progenitor cells as PV-positive cells are also altered by TH deficiency. The number of PV-positive interneurons was significantly decreased in the neocortex and hippocampus of grt mice as compared with normal control mice. In contrast to the decrease in the number of PV neurons, the number of Sst-positive interneurons in grt mice was increased in the stratum oriens of the hippocampus and the hilus of the dentate gyrus, although their number was unchanged in the neocortex. These changes were reversed by triiodothyronine administration from postnatal day (PD) 0 to 20. TH supplementation that was initiated after PD21 did not, however, affect the number of PV- or Sst-positive cells. These results suggest that during the first three postnatal weeks, TH may be critical for the generation of subpopulations of interneurons.