Chronotropic response of isolated atria to acid base alterations.
Chronotropic response of isolated atria to acid base alterations.
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孤立心房对酸碱变化的变时反应。
DOI：
10.3109/13813457809055959
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
E. Cingolani
中科院分区：
文献类型：
--
作者：
O. Gende;M. C. Camilión de Hurtado;E. Cingolani
使用暴露于通过添加HCl或通过增加孵育培养基中的PCO2产生的累积程度的酸中毒的离体心房，分析酸碱改变对自发速率的影响。绘制频率与pH曲线，以评估对酸碱变化的变时性反应。心率增加，并降低时，pH值的介质降低。“呼吸”和“代谢”的改变对收缩率的影响程度相同。从正常值降低pH值似乎降低心率超过由相同的pH值变化产生的增强朝着中风侧。当将频率绘制为氢离子活性（aH+）的函数时，无论是纯粹的“代谢”还是“呼吸”酸碱变化，都获得了更线性的关系。从正常值增加（aH+）似乎使心率降低的程度（呼吸改变）或甚至低于（代谢改变）由（aH+）向痉挛侧的相同变化产生的增强。阿托品或心得安阻断神经递质，既不能阻止由酸中毒引起的心率增加，也不能阻止酸中毒引起的心率减少。
The effect of acid-base alterations on spontaneous rate was analysed using isolated atria exposed to cumulative degrees of acidosis produced either by adding HCl or by increasing PCO2 in the incubation medium. Frequncy vs. pH curves were made to assess chronotropic response to acid-base changes. Heart rate was increased in alkalosis and decreased when the pH of the medium was lowered. Both "respiratory" and "metabolic" alterations affected the contraction rate to the same extent. Decreasing pH from normal values seemed to decrease heart rate more than the enhancement produced by the same change in pH towards the alkalotic side. When frequency was plotted as a function of hydrogen ion activity (aH+) a more linear relationship was obtained, either with pure "metabolic" or with "respiratory" acid-base alterations. Increasing (aH+) from normal values seemed to decrease heart rate to the same extent (respiratory alterations) or even less (metabolic alterations) than the enhancement produced by the same change in (aH+) towards the alkalotic side. Neither the increase in rate produced by alkalosis nor the decrease induced by acidosis were prevented by blocking the neurotransmitters by atropine or propranolol.