MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a.
MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a.
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DOI：
10.1016/j.jneuroim.2014.11.004
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发表时间：
2015-01-15
影响因子：
3.3
通讯作者：
Balashov, Konstantin E.
中科院分区：
文献类型：
--
作者：
Aung, Latt Latt;Mouradian, M. Maral;Dhib-Jalbut, Suhayl;Balashov, Konstantin E.
B细胞是维持复发性多发性硬化症（MS）的疾病活动所必需的，并产生破坏血脑屏障的基质金属肽酶-9（MMP-9）。与缓解期相比，在疾病复发期间MS患者的B淋巴细胞中，MMP-9蛋白表达增加，靶向MMP-9 mRNA的microRNA-320 a（miR-320 a）表达显著降低。通过用miR-320 a抑制剂转染人B淋巴细胞，从而导致MMP-9表达和分泌增加，证实了这些发现的功能意义。总之，MS患者的B细胞中miR-320 a的表达降低，可能导致血脑屏障通透性增加和神经功能障碍。
B cells are necessary to maintain disease activity in relapsing multiple sclerosis (MS) and produce matrix metallopeptidase-9 (MMP-9), which disrupts the blood-brain barrier. MMP-9 protein expression was increased and expression of microRNA-320a (miR-320a), which targets MMP-9 mRNA, was significantly decreased in B lymphocytes of MS patients during a disease relapse compared to remission. Functional significance of these findings was demonstrated by transfecting human B lymphocytes with miR-320a inhibitor, which led to increased MMP-9 expression and secretion. In summary, expression of miR-320a is decreased in B cells of MS patients and may contribute to increased blood-brain barrier permeability and neurological disability.
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
14.5
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作者：
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作者：
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通讯作者：
Leib, SL
DOI：
10.1126/science.1222794
发表时间：
2012-09-07
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Stamatoyannopoulos JA