Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver
Characterization and prognosis of patients with hepatocellular carcinoma (HCC) in the non-cirrhotic liver
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DOI：
10.1186/1471-230x-14-117
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发表时间：
2014-07-03
影响因子：
2.4
通讯作者：
Malfertheiner, Peter
中科院分区：
文献类型：
--
作者：
Schuette, Kerstin;Schulz, Christian;Malfertheiner, Peter
背景：肝癌主要发生在慢性炎症导致肝硬化的情况下。一小部分患有HCC的患者在非炎性肝脏（NCL）中被诊断。在NCL中晚期HCC患者的数据是稀缺的stage.Methods：进行回顾性分析，比较93例NCL中HCC患者与571例肝硬化（LC）中HCC患者的临床和人口统计学特征。结果：NCL中的HCC患者比LC患者诊断年龄更大，肿瘤分期更晚。超过25%的NCL HCC患者出现肝外转移。只有少数NCL中的HCC患者缺乏任何肝损伤迹象。LC的风险因素和NAFLD的风险因素存在于大多数NCL中的HCC患者中。BCLC分类对应于生存的HCC患者在NCL虽然不同的治疗方案与肝硬化patients with liver cirrhosis.Conclusions：这将是在未来的主要挑战之一，以清醒的意识，除了肝硬化，特别是在NAFLD的慢性肝病患者的肝脏恶性肿瘤的风险。如果监测方案具有成本效益，就需要实施这些方案。
Background: HCC predominantly develops in the condition of chronic inflammation that has led to liver cirrhosis. A small proportion of patients with HCC is diagnosed in the non-cirrhotic liver (NCL). Data on patients with HCC in NCL in advanced stages are scarce.Methods: A retrospective analysis was performed comparing 93 patients with HCC in NCL to 571 patients with HCC in liver cirrhosis (LC) with respect to clinical and demographic characteristics. Also factors influencing survival in patients with HCC in NCL were analyzed.Results: Patients with HCC in NCL were diagnosed at older age and in more advanced tumor stages than patients with LC. More than 25% of patients with HCC in NCL presented with extrahepatic metastases. Only a minority of patients with HCC in NCL lacked any sign of hepatic damage. Risk factors for LC and risk factors for NAFLD are present in the majority of patients with HCC in NCL. The BCLC classification corresponded with the survival of patients with HCC in NCL although the therapeutic options differ from those for patients with liver cirrhosis.Conclusions: It will be one of the major challenges in the future to awake awareness of carrying a risk of hepatic malignancies in patients with chronic liver diseases apart from liver cirrhosis, especially in NAFLD. Surveillance programs need to be implemented if these are cost-effective.