Time Course of Heart Rate Variability Response to PM2.5 Exposure from Secondhand Smoke.
Time Course of Heart Rate Variability Response to PM2.5 Exposure from Secondhand Smoke.
复制标题
DOI：
10.1371/journal.pone.0154783
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Cavallari JM
中科院分区：
文献类型：
--
作者：
Garza JL;Mittleman MA;Zhang J;Christiani DC;Cavallari JM
目的：暴露于二手烟（SHS）与心率变异性（HRV）降低有关。然而，这种关联的时间过程尚不清楚。因此，本研究的目的是调查15-240分钟SHS相关的细颗粒物（PM2.5）移动平均值和HRV指数之间的关联。研究方法：通过小组研究设计，我们使用个人监测器连续测量35名暴露于SHS约6小时的参与者的PM2.5和HRV。结果如下：我们观察到5分钟HRV指数与15分钟PM2.5移动平均值和240分钟PM2.5移动平均值之间存在负的显著关联：有显著（p<0.01）与（RMSSD）相关的连续正常心跳均方差的5分钟平方根降低7.5%，和重大（p<0.01）与15分钟PM2.5移动平均值相关的5分钟高频（HF）功率降低14.7%;也有显著（p<0.01）5分钟RMSSD降低46.9%，与240分钟PM2.5移动平均值相关的5分钟高频（HF）功率显著（p<0.01）降低77.7%。结论：我们的研究结果表明，暴露于SHS相关的PM2.5与HRV相关支持的假设，SHS可以影响心血管系统。短期和长期PM2.5和HRV之间的负相关性表明SHS对心血管系统的不良影响。
Purpose: Exposure to secondhand smoke (SHS) has been associated with decreased heart rate variability (HRV). However, the time course of this association is unclear. Therefore, the objective of this study was to investigate the association between 15–240 minute SHS-related fine particulate matter (PM2.5) moving averages and indices of HRV. Methods: With a panel study design, we used personal monitors to continuously measure PM2.5 and HRV of 35 participants who were exposed to SHS for approximately 6 hours. Results: We observed negative, significant associations between 5-minute HRV indices and 15 minute PM2.5 moving averages and 240 minute PM2.5 moving averages: there was a significant (p<0.01) 7.5% decrease in the 5-minute square root of the mean squared differences of successive normal heart beats associated with (RMSSD), and a significant (p<0.01) 14.7% decrease in the 5-minute high frequency (HF) power associated with the 15 minute PM2.5 moving averages; there was also a significant (p<0.01) 46.9% decrease in the 5-minute RMSSD, and a significant (p<0.01) 77.7% decrease in the 5-minute high frequency (HF) power associated with the 240 minute PM2.5 moving averages. Conclusions: Our findings that exposure to SHS related PM2.5 was associated with HRV support the hypothesis that SHS can affect the cardiovascular system. The negative associations reported between short and longer term PM2.5 and HRV indicate adverse effects of SHS on the cardiovascular system.