Influence of body composition on bone mass in postmenopausal osteoporotic women
Influence of body composition on bone mass in postmenopausal osteoporotic women
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DOI：
10.1016/j.archger.2009.12.006
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发表时间：
2010-11-01
影响因子：
4
通讯作者：
Martini, Ligia A.
中科院分区：
文献类型：
--
作者：
Genaro, Patricia S.;Pereira, Giselle A. P.;Martini, Ligia A.
我们的目的是评估绝经后妇女的瘦体重和脂肪量与骨量的关系。我们邀请了65名在圣保罗医院骨质疏松症门诊接受治疗的妇女参加。采用双能X线吸收法（DXA）测量身体成分和骨密度（BMD）。平均年龄和体重分别为69.7 ± 6.4岁和56.3 ± 7.6 kg。按体重指数（BMI）计算，52.8%的患者体重正常，47.1%的患者超重。超重的妇女有显着较高的骨量。同样，骨骼肌指数（SMI）显示出积极的影响，BMD测量和妇女与肌肉减少症有显着较低的BMD测量在总股骨和股骨颈。在多元回归分析中，只有瘦体重和年龄，在调整脂肪量和BMI后，能够预测全身骨矿物质含量（BMC）（R（2）= 28%）。根据年龄和BMI调整的瘦体重也能够预测股骨颈BMD（R（2）= 14%）。另一方面，没有身体成分（瘦体重或脂肪量）的组成部分显着解释总股骨BMD和身体成分测量与脊柱BMD。这些发现表明，瘦体重在BMC和BMD测量中具有相关作用。此外，较低的BMI和瘦体重减少（肌肉减少症）与股骨颈和全股骨的BMC和BMD较低以及可能的骨质疏松性骨折的风险较高相关。(C)2010爱思唯尔爱尔兰有限公司版权所有。
We aimed at evaluating the relationship of lean and fat mass to bone mass in osteoporotic postmenopausal women. We invited 65 women who were being treated at the Sao Paulo Hospital osteoporosis outpatients' clinic to participate. Body composition and bone mineral density (BMD) measurements were performed using Dual-energy X-ray absorptiometry methodology (DXA). The mean age and weight were 69.7 +/- 6.4 years and 56.3 +/- 7.6 kg, respectively. Accordingly to the body mass index (BMI), 52.8% were of normal weight and 47.1% of the patients were overweight. Overweight women had significantly higher bone mass. Similarly, skeletal muscle index (SMI) showed a positive effect on BMD measurements and women with sarcopenia had significantly lower BMD measurements in total femur and femoral neck. In multiple regression analysis only lean mass and age, after adjustments to fat mass and BMI, were able to predict total body bone mineral content (BMC) (R(2) = 28%). Also lean mass adjusted to age and BMI were able to predict femoral neck BMD (R(2) = 14%). On the other hand, none of the components of the body composition (lean mass or fat mass) contributed significantly to explaining total femur BMD and neither body composition measurements were associated with spine BMD. These findings suggest that lean mass has a relevant role in BMC and BMD measurements. In addition, lower BMI and lean mass loss (sarcopenia) is associated to lower BMC and BMD of femoral neck and total femur and possible higher risk of osteoporotic fracture. (C) 2010 Elsevier Ireland Ltd. All rights reserved.