Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015.
Two waves of coeliac disease incidence in Sweden: a nationwide population-based cohort study from 1990 to 2015.
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DOI：
10.1136/gutjnl-2021-324209
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发表时间：
2022-06
期刊：
影响因子：
24.5
通讯作者：
Ludvigsson, Jonas F.
中科院分区：
文献类型：
--
作者：
Bergman, David;King, James;Lebwohl, Benjamin;Clements, Mark S.;Roelstraete, Bjorn;Kaplan, Gilaad G.;Green, Peter H. R.;Murray, Joseph A.;Ludvigsson, Jonas F.
评估瑞典活检证实的乳糜泻（CD）的发生率，并检查随时间推移十二指肠/空肠活检正常粘膜的发生率，作为CD意识和调查的代表。1990-2015年基于活检报告的全国人群队列研究，表明十二指肠/空肠中存在绒毛萎缩（VA）或正常粘膜。我们确定了44771例（63%女性）的活检报告表明VA和412279例（62%女性）的活检报告表明正常粘膜（没有事先活检表明VA）。CD诊断时的中位年龄为28岁。研究期间的平均年龄标准化发病率为19.0/100 000人-年（95% CI 17.3 - 20.8）。1994年男女发病率均达到高峰，2002-2003年女性和2006年男性的发病率分别达到第二个高峰。发生CD的终生风险为1.8%（女性2.3%，男性1.4%）。在2015年之前，活检显示十二指肠/空肠粘膜正常的比率平行上升。在瑞典，女性CD发病率在2002-2003年之前增加，男性在2006年之前增加。从那时起，CD的发病率下降，尽管增加十二指肠/空肠活检，这表明提高认识和调查不太可能提高瑞典的发病率。在一生中，瑞典44名女性中有1名和72名男性中有1名预计被诊断为CD，表明疾病的社会负担相对较高。
To assess the incidence of biopsy-verified coeliac disease (CD) in Sweden and examine the incidence of duodenal/jejunal biopsies with normal mucosa over time as a proxy for CD awareness and investigation. Nationwide population-based cohort study 1990–2015 based on biopsy reports indicating villous atrophy (VA) or normal mucosa in the duodenum/jejunum. We identified 44 771 individuals (63% females) with a biopsy report specifying VA and 412 279 (62% females) with a biopsy report indicating normal mucosa (without a prior biopsy indicating VA). The median age at diagnosis of CD was 28 years. The mean age-standardised incidence rate during the study period was 19.0 per 100 000 person-years (95% CI 17.3 to 20.8). The incidence reached a peak in 1994 for both sexes and a second higher peak in 2002–2003 for females and in 2006 for males. The lifetime risk of developing CD was 1.8% (2.3% in females and 1.4% in males). Prior to 2015, there was a parallel rise in rates for biopsies showing normal duodenal/jejunal mucosa. In Sweden, the incidence of CD increased until 2002–2003 in females and until 2006 in males. Since then, the incidence of CD has declined despite increasing duodenal/jejunal biopsies, suggesting that increased awareness and investigation are unlikely to elevate the incidence of the disease in Sweden. Across a lifetime, 1 in 44 females and 1 in 72 males are expected to be diagnosed with CD in Sweden, indicating a relatively high societal burden of disease.
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影响因子：
29.4
作者：
Choung RS;Larson SA;Khaleghi S;Rubio-Tapia A;Ovsyannikova IG;King KS;Larson JJ;Lahr BD;Poland GA;Camilleri MJ;Murray JA
通讯作者：
Murray JA
DOI：
10.1097/mpg.0b013e31821a23d0
发表时间：
2012-01-01
影响因子：
2.9
作者：
Husby, S.;Koletzko, S.;Zimmer, K. P.
通讯作者：
Zimmer, K. P.
影响因子：
3.8
作者：
Ivarsson, A;Persson, LÅ;Hernell, O
通讯作者：
Hernell, O
影响因子：
10.3
作者：
Elfstrom, Peter;Granath, Fredrik;Ludvigsson, Jonas F.
通讯作者：
Ludvigsson, Jonas F.
影响因子：
4.4
作者：
Catassi, Carlo;Kryszak, Debby;Fasano, Alessio
通讯作者：
Fasano, Alessio