Visual physiology of the layer 4 cortical circuit in silico
Visual physiology of the layer 4 cortical circuit in silico
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DOI：
10.1371/journal.pcbi.1006535
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发表时间：
2018-11-01
影响因子：
4.3
通讯作者：
Koch, Christof
中科院分区：
文献类型：
--
作者：
Arkhipov, Anton;Gouwens, Nathan W.;Koch, Christof
尽管在实验技术和积累的大型数据集的组成和性质的皮层，定量建模的皮质电路在体内的条件下仍然具有挑战性。在这里，我们报告并公开发布了一个生物物理详细的电路模型，在小鼠初级视觉皮层的第4层，接受丘脑皮层的视觉输入。45，000个神经元模型接受了一系列视觉刺激，并将结果与已发表的工作和新的体内实验进行了比较。模拟再现了各种观察结果，包括光遗传学扰动的影响。计算机模拟和体内反应之间的一致性的关键是神经元之间功能性突触连接的规则。有趣的是，经过极端简化后，该模型在许多测量上仍然表现令人满意，尽管与实验的定量一致性受到了影响。这些结果强调了皮层布线的功能规则的重要性，并使下一代的数据驱动模型的体内神经活动和计算。
Despite advances in experimental techniques and accumulation of large datasets concerning the composition and properties of the cortex, quantitative modeling of cortical circuits under in-vivo-like conditions remains challenging. Here we report and publicly release a bio-physically detailed circuit model of layer 4 in the mouse primary visual cortex, receiving thalamo-cortical visual inputs. The 45,000-neuron model was subjected to a battery of visual stimuli, and results were compared to published work and new in vivo experiments. Simulations reproduced a variety of observations, including effects of optogenetic perturbations. Critical to the agreement between responses in silico and in vivo were the rules of functional synaptic connectivity between neurons. Interestingly, after extreme simplification the model still performed satisfactorily on many measurements, although quantitative agreement with experiments suffered. These results emphasize the importance of functional rules of cortical wiring and enable a next generation of data-driven models of in vivo neural activity and computations.