Effects of sevoflurane and isoflurane on electrocorticographic activities in patients with temporal lobe epilepsy
Effects of sevoflurane and isoflurane on electrocorticographic activities in patients with temporal lobe epilepsy
复制标题
DOI：
10.1097/00008506-200110000-00010
复制
发表时间：
2001-10-01
影响因子：
3.7
通讯作者：
Fukui, M
中科院分区：
文献类型：
--
作者：
Hisada, K;Morioka, T;Fukui, M
为了比较七氟醚和异氟醚的神经兴奋作用，我们记录了6例颞叶癫痫（TLE）患者清醒期间以及七氟醚和异氟醚麻醉期间的皮层脑电图（ECoG）。这些患者在颞区长期植入硬膜下栅极电极。在1.5最小肺泡浓度（MAC）的七氟烷麻醉期间，与67%一氧化二氮（N2O）的组合，在4例患者中观察到发作间期阵发性活动显著增加。2例患者阵发性活动轻微增加。激活区分布广泛，不局限于自发性癫痫发作的发作区。然而，异氟醚麻醉在1.5 MAC的组合与67%的N2O与阵发性活动增加较少。虽然七氟烷的神经兴奋特性被证明大于异氟烷，但广泛的刺激性。对七氟烷给药的反应对定位致痫区域没有帮助。
To compare the neuroexcitatory effects of sevoflurane and isoflurane, we recorded electrocorticograms (ECoG) during wakefulness and during sevoflurane and isoflurane anesthesia in six patients with temporal lobe epilepsy (TLE). These patients had subdural grid electrodes chronically implanted in the temporal region. During sevoflurane anesthesia at 1.5 minimum alveolar concentration (MAC) of the combination with 67% nitrous oxide (N2O), a marked increase in interictal paroxysmal activities was observed in four patients. Two patients had a slight increase in paroxysmal activities. Activated areas were widely distributed, not being confined to the ictal onset zone of spontaneous seizures. However, isoflurane anesthesia at 1.5 MAC of the combination with 67% N2O was associated with less increased paroxysmal activity. While the neuroexcitatory properties of sevoflurane proved greater than those of isoflurane, the widespread irritative. response to sevoflurane administration was not helpful in localizing the epileptogenic area.