Stromal Cells Underlining the Paths From Autoimmunity, Inflammation to Cancer With Roles Beyond Structural and Nutritional Support.
Stromal Cells Underlining the Paths From Autoimmunity, Inflammation to Cancer With Roles Beyond Structural and Nutritional Support.
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DOI：
10.3389/fcell.2021.658984
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发表时间：
2021
影响因子：
5.5
通讯作者：
Chen Z
中科院分区：
文献类型：
--
作者：
Honan AM;Chen Z
基质细胞在次级淋巴器官和非淋巴组织中提供结构支持和营养。然而，越来越多的证据表明，基质细胞和免疫细胞之间存在复杂的关系。免疫细胞和基质细胞之间的相互作用已被证明会影响自身免疫和癌症的病理学。这篇综述探讨了在稳态和炎症条件下，特别是自身免疫和癌症，淋巴结和非淋巴组织内基质细胞的异质性，目的是更好地了解这两类疾病之间复杂和明显矛盾的关系。该综述调查了涉及基质细胞和免疫细胞之间相互作用的潜在新机制，这些机制可能有助于自身免疫和癌症之间的发展，病理和潜在联系，包括从自身免疫炎症到“热”或“冷”肿瘤的潜在途径。这些相互作用可能提供一些见解，以解释在工业化国家的年轻女性的自身免疫和癌症的发病率不断上升，并有可能被利用在预防和治疗自身免疫性疾病和癌症的新的干预措施的发展。
Stromal cells provide structural support and nutrients in secondary lymphoid organs and non-lymphoid tissues. However, accumulating evidence suggests that a complex relationship exists between stromal cells and immune cells. Interactions between immune cells and stromal cells have been shown to influence the pathology of both autoimmunity and cancer. This review examines the heterogeneity of stromal cells within the lymph node and non-lymphoid tissues during both homeostatic and inflammatory conditions, in particular autoimmunity and cancer, with the goal of better understanding the complex and apparently paradoxical relationship between these two classes of diseases. The review surveys potential novel mechanisms involving the interactions between stromal cells and immune cells which may contribute to the development, pathology and underlying connection between autoimmunity and cancer, including potential pathways from autoimmune inflammation to either “hot” or “cold” tumors. These interactions may provide some insights to explain the rising incidence of both autoimmunity and cancer in young women in industrialized countries and have the potential to be exploited in the development of new interventions for preventions and treatments of both autoimmune diseases and cancer.
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DOI：
10.4049/jimmunol.1200077
发表时间：
2012-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Hedrick SM
通讯作者：
Hedrick SM
影响因子：
4.4
作者：
Bouzin, Caroline;Brouet, Agnes;Feron, Olivier
通讯作者：
Feron, Olivier
影响因子：
10.3
作者：
Anderson, William F.;Rabkin, Charles S.;Camargo, M. Constanza
通讯作者：
Camargo, M. Constanza
影响因子：
56.9
作者：
Anderson, MS;Venanzi, ES;Mathis, D
通讯作者：
Mathis, D
影响因子：
7.3
作者：
Berendam, Stella J.;Koeppel, Alexander F.;Engelhard, Victor H.
通讯作者：
Engelhard, Victor H.