Non-viral COVID-19 vaccine delivery systems.

Non-viral COVID-19 vaccine delivery systems.
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非病毒性COVID-19疫苗递送系统。

DOI:
10.1016/j.addr.2020.12.008
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发表时间:
2021-03
影响因子:
16.1
通讯作者:
Moon JJ
Moon JJ
中科院分区:
医学1区
文献类型:
--
作者:
Park KS;Sun X;Aikins ME;Moon JJ

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被称为严重急性呼吸道综合征冠状病毒2(SARS-CoV-2)的新型冠状病毒以惊人的速度在地球仪传播,在2019年12月报告的不到一年时间里,造成数千万病例和100多万人死亡。从那时起,公司和研究机构竞相开发SARS-CoV-2疫苗,从传统的病毒和蛋白质疫苗到更先进的疫苗,包括DNA和mRNA疫苗。每种疫苗表现出不同的效力和效力持续时间,如由抗原设计、佐剂分子、疫苗递送平台和免疫方法所确定的。在这篇综述中,我们将介绍一些处于临床阶段开发的领先非病毒疫苗,并讨论提高疫苗有效性、保护期、安全性和大规模接种的交付策略。
The novel corona virus termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread throughout the globe at a formidable speed, causing tens of millions of cases and more than one million deaths in less than a year of its report in December 2019. Since then, companies and research institutions have raced to develop SARS-CoV-2 vaccines, ranging from conventional viral and protein-based vaccines to those that are more cutting edge, including DNA- and mRNA-based vaccines. Each vaccine exhibits a different potency and duration of efficacy, as determined by the antigen design, adjuvant molecules, vaccine delivery platforms, and immunization method. In this review, we will introduce a few of the leading non-viral vaccines that are under clinical stage development and discuss delivery strategies to improve vaccine efficacy, duration of protection, safety, and mass vaccination.
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