High-throughput screening of improved protease inhibitors using a yeast cell surface display system and a yeast cell chip
High-throughput screening of improved protease inhibitors using a yeast cell surface display system and a yeast cell chip
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DOI：
10.1016/j.jbiosc.2010.08.006
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发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Ueda, Mitsuyoshi
中科院分区：
文献类型：
--
作者：
Aoki, Wataru;Yoshino, Yuichi;Ueda, Mitsuyoshi
蛋白酶靶向抑制剂是一种很有前途的药物。本研究将酵母细胞表面展示系统与酵母细胞芯片相结合，用于蛋白酶抑制剂的高通量筛选，并成功地提高了蛋白酶抑制剂的活性。(C)2010年，生物技术学会，日本。All rights reserved.
Protease-targeted inhibitors have been promising pharmaceuticals. Here, we combined a yeast cell surface display system with a yeast cell chip for the high-throughput screening of protease inhibitors, and succeeded in improving the activity of a protease inhibitor. (C) 2010, The Society for Biotechnology, Japan. All rights reserved.