Catalytic Generation of Arynes and Trapping by Nucleophilic Addition and Iodination
Catalytic Generation of Arynes and Trapping by Nucleophilic Addition and Iodination
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DOI：
10.1002/anie.201108415
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Suzuki, Keisuke
中科院分区：
文献类型：
--
作者：
Hamura, Toshiyuki;Chuda, Yu;Suzuki, Keisuke
一个公平的交换：在标题反应中，炔基锂作为引发剂，通过碘-锂交换生成苯炔。当在化学计量量的亲核试剂存在下进行时，所产生的苯炔经受锂亲核试剂的攻击以产生芳基锂，然后芳基锂被碘代炔碘化以得到碘代芳烃1。
A fair exchange: in the title reaction, alkynyllithium serves as an initiator for benzyne generation through an iodine-lithium exchange. When performed in the presence of stoichiometric amounts of a nucleophile, the generated benzyne undergoes attack by lithio nucleophiles to generate aryllithium, which is then iodinated by iodoalkyne to give the iodoarenes 1.