A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite
A Single SNP Turns a Social Honey Bee (Apis mellifera) Worker into a Selfish Parasite
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DOI：
10.1093/molbev/msy232
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发表时间：
2019-03-01
影响因子：
10.7
通讯作者：
Moritz, Robin F. A.
中科院分区：
文献类型：
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作者：
Aumer, Denise;Stolle, Eckart;Moritz, Robin F. A.
复杂昆虫社会中利他主义的进化可以说是进化中的主要转变之一，包容性适应性理论合理地解释了为什么这是一种进化稳定策略。然而，南非开普蜜蜂（Apis mellifera capensis）的工蜂可以通过成为社会寄生虫和孤雌生殖产生雌性后代（产雌孤雌生殖）来扭转自私行为。使用联合作图和群体基因组学方法，结合时程转录本丰度动态分析，我们表明，所绘制的产雌孤雌基因座（Th）处的单核苷酸多态性与标志性的产雌孤雌表型相关。在基因组的强烈选择下，Th 与非重组区域内的蜕皮触发激素受体 (Ethr) 形成连锁基团。平衡的有害等位基因系统似乎可以解释为什么该性状是 A. m. 所特有的。 capensis 无法轻易将其自身融入其他蜜蜂亚种的基因组中。
The evolution of altruism in complex insect societies is arguably one of the major transitions in evolution and inclusive fitness theory plausibly explains why this is an evolutionary stable strategy. Yet, workers of the South African Cape honey bee (Apis mellifera capensis) can reverse to selfish behavior by becoming social parasites and parthenogenetically producing female offspring (thelytoky). Using a joint mapping and population genomics approach, in combination with a time-course transcript abundance dynamics analysis, we show that a single nucleotide polymorphism at the mapped thelytoky locus (Th) is associated with the iconic thelytokous phenotype. Th forms a linkage group with the ecdysis-triggering hormone receptor (Ethr) within a nonrecombining region under strong selection in the genome. A balanced detrimental allele system plausibly explains why the trait is specific to A. m. capensis and cannot easily establish itself into genomes of other honey bee subspecies.