Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury
Role of Macrophage Migration Inhibitory Factor in Hepatitis B Virus-Specific Cytotoxic-T-Lymphocyte-Induced Liver Injury
复制标题
DOI：
10.1128/cvi.13.3.415-419.2006
复制
发表时间：
2006-03
影响因子：
--
通讯作者：
K. Kimura;M. Nagaki;J. Nishihira†;S. Satake;Kazuo Kuwata;H. Moriwaki
中科院分区：
文献类型：
--
作者：
K. Kimura;M. Nagaki;J. Nishihira†;S. Satake;Kazuo Kuwata;H. Moriwaki
摘要巨噬细胞移动抑制因子(MIF)在多种炎症性疾病的发生发展中起着关键作用。在这里，我们发现，在乙肝病毒转基因小鼠体内注射抗原特异性细胞毒性T淋巴细胞后，抗鼠MIF抗体治疗减少了肝损伤和炎症细胞向肝脏的渗透。
ABSTRACT Macrophage migration inhibitory factor (MIF) plays a pivotal role in the development of various inflammatory diseases. Here, we found that anti-mouse MIF antibody treatment reduced liver injury and inflammatory cell infiltration into the liver after injection of antigen-specific cytotoxic T lymphocytes into hepatitis B virus transgenic mice.